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C. C. Swisher Xiaolin Wang Zhonghe Zhou Yuanqing Wang Fan Jin Jiangyong Zhang Xing Xu Fucheng Zhang Yuan Wang 《科学通报(英文版)》2002,47(2):136-139
We report new 40Ar÷39Ar dating results obtained from total fusion and incremental-heating analyses of sanidine and biotite from three tuffs found
interbedded within the fossil-bearing deposits of Liaoning, northeast China. The first is a new sample of the Bed 6 Sihetun
tuff from the Yixian Formation, previously dated by our team as middle Early Cretaceous, and recently considered by Lo et
al., partially reset due to metamorphism from a nearby basaltic sill. The second is the Yixian Bed 9 tuff from Hengdaozi considered
by Lo et al. to be unaffected by metamorphism and whose age, based on total fusion 40Ar÷39Ar dating of biotite, argues for a Jurassic age for the Yixian Formation. The third tuff is a previously undated tuff from
the upper part of the underlying Tuchengzi Formation. Single crystal total fusion 40Ar÷39Ar analyses of the Sihetun sanidine showed homogeneous radiogenic Ar, Ca÷K ratios, excellent reproducibility and gave a mean
age of 125.0±0.18 (1SD)±0.04 (SE) Ma. Single sanidine crystal total fusion 40Ar÷39Ar analyses of the Hengdaozi tuff gave a mean age of 125.0±0.19 (1SD)±0.04 (SE) Ma, which is indistinguishable from the Sihetun
tuff. The Tuchengzi Formation tuff gave a mean age of 139.4±0.19 (1SD)±0.05 (SE) Ma. Detailed laser incremental-heating analyses
of biotite from Sihetun, Hengdaozi, and Tuchengzi tuffs show disturbed Ar release patterns and evidence of trapped argon components.
We conclude from these analyses that the total fusion dates on biotite by Lo et al. are erroneously old and isotopic dating
of both biotite and sanidine from tuffs of the Yixian Formation point to a middle Early Cretaceous age. The upper part of
the Tuchengzi Formation can be referred to the Early Cretaceous. 相似文献
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Sakai W Swisher EM Karlan BY Agarwal MK Higgins J Friedman C Villegas E Jacquemont C Farrugia DJ Couch FJ Urban N Taniguchi T 《Nature》2008,451(7182):1116-1120
Ovarian carcinomas with mutations in the tumour suppressor BRCA2 are particularly sensitive to platinum compounds. However, such carcinomas ultimately develop cisplatin resistance. The mechanism of that resistance is largely unknown. Here we show that acquired resistance to cisplatin can be mediated by secondary intragenic mutations in BRCA2 that restore the wild-type BRCA2 reading frame. First, in a cisplatin-resistant BRCA2-mutated breast-cancer cell line, HCC1428, a secondary genetic change in BRCA2 rescued BRCA2 function. Second, cisplatin selection of a BRCA2-mutated pancreatic cancer cell line, Capan-1 (refs 3, 4), led to five different secondary mutations that restored the wild-type BRCA2 reading frame. All clones with secondary mutations were resistant both to cisplatin and to a poly(ADP-ribose) polymerase (PARP) inhibitor (AG14361). Finally, we evaluated recurrent cancers from patients whose primary BRCA2-mutated ovarian carcinomas were treated with cisplatin. The recurrent tumour that acquired cisplatin resistance had undergone reversion of its BRCA2 mutation. Our results suggest that secondary mutations that restore the wild-type BRCA2 reading frame may be a major clinical mediator of acquired resistance to platinum-based chemotherapy. 相似文献
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C. C. Swisher III WANG Xiaolin ZHOU Zhonghe WANG Yuanqing JIN Fan ZHANG Jiangyong XU Xing ZHANG Fucheng WANG Yuan 《科学通报(英文版)》2002,47(2):135-138
We report new 40Ar/39Ar dating results obtained from total fusion and incremental-heating analyses of sanidine and biotite from three tuffs found interbedded within the fossil-bearing deposits of Liaoning, northeast China. The first is a new sample of the Bed 6 Sihetun tuff from the Yixian Formation, previously dated by our team as middle Early Cretaceous, and recently considered by Lo et al., partially reset due to metamorphism from a nearby basaltic sill. The second is the Yixian Bed 9 tuff from Hengdaozi considered by Lo et al. to be unaffected by metamorphism and whose age, based on total fusion 40Ar/39Ar dating of biotite, argues for a Jurassic age for the Yixian Formation. The third tuff is a previously undated tuff from the upper part of the underlying Tuchengzi Formation. Single crystal total fusion 40Ar/39Ar analyses of the Sihetun sanidine showed homogeneous radiogenic Ar, Ca/K ratios, excellent reproducibility and gave a mean age of 125.0 ± 0.18 (1SD) ± 0.04 (SE) Ma. Single sanidine crystal total fusion 40Ar/39Ar analyses of the Hengdaozi tuff gave a mean age of 125.0 ± 0.19 (1SD) ± 0.04 (SE) Ma, which is indistinguishable from the Sihetun tuff. The Tuchengzi Formation tuff gave a mean age of 139.4 ± 0.19 (1SD) ± 0.05 (SE) Ma. Detailed laser incremental-heating analyses of biotite from Sihetun, Hengdaozi, and Tuchengzi tuffs show disturbed Ar release patterns and evidence of trapped argon components. We conclude from these analyses that the total fusion dates on biotite by Lo et al. are erroneously old and isotopic dating of both biotite and sanidine from tuffs of the Yixian Formation point to a middle Early Cretaceous age. The upper part of the Tuchengzi Formation can be referred to the Early Cretaceous. 相似文献
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