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排序方式: 共有138条查询结果,搜索用时 15 毫秒
1.
A SUMOylation-defective MITF germline mutation predisposes to melanoma and renal carcinoma 总被引:1,自引:0,他引:1
Bertolotto C Lesueur F Giuliano S Strub T de Lichy M Bille K Dessen P d'Hayer B Mohamdi H Remenieras A Maubec E de la Fouchardière A Molinié V Vabres P Dalle S Poulalhon N Martin-Denavit T Thomas L Andry-Benzaquen P Dupin N Boitier F Rossi A Perrot JL Labeille B Robert C Escudier B Caron O Brugières L Saule S Gardie B Gad S Richard S Couturier J Teh BT Ghiorzo P Pastorino L Puig S Badenas C Olsson H Ingvar C Rouleau E Lidereau R Bahadoran P Vielh P Corda E Blanché H Zelenika D 《Nature》2011,480(7375):94-98
2.
Molecular and Cellular Basis of Regeneration and Tissue Repair 总被引:3,自引:0,他引:3
Rossi L Salvetti A Batistoni R Deri P Gremigni V 《Cellular and molecular life sciences : CMLS》2008,65(1):16-23
Planarians possess amazing abilities to regulate tissue homeostasis and regenerate missing body parts. These features reside on the presence of a population of pluripotent/totipotent stem cells, the neoblasts, which are considered as the only planarian cells able to proliferate in the asexual strains. Neoblast distribution has been identified by mapping the cells incorporating bromodeoxyuridine, analyzing mitotic figures and using cell proliferation markers. Recently identified molecular markers specifically label subgroups of neoblasts, revealing thus the heterogeneity of the planarian stem cell population. Therefore, the apparent totipotency of neoblasts probably reflects the composite activities of multiple stem cell types. First steps have been undertaken to understand how neoblasts and differentiated cells communicate with each other to adapt the self-renewal and differentiation rates of neoblasts to the demands of the body. Moreover, the introduction of molecular resource database on planarians now paves the way to renewed strategies to understand planarian regeneration and stem cell-related issues. 相似文献
3.
Montuori N Bifulco K Carriero MV La Penna C Visconte V Alfano D Pesapane A Rossi FW Salzano S Rossi G Ragno P 《Cellular and molecular life sciences : CMLS》2011,68(14):2453-2467
The receptor (CXCR4) for the stromal-derived factor-1 (SDF1) and the urokinase-receptor (uPAR) are up-regulated in various tumors. We show that CXCR4-transfected cells migrate toward SDF1 on collagen (CG) and do not on vitronectin (VN). Co-expression of cell-surface uPAR, which is a VN receptor, impairs SDF1-induced migration on CG and allows migration on VN. Blocking fMLP receptors (fMLP-R), alpha-v integrins or the uPAR region capable to interact with fMLP-Rs, impairs migration of uPAR/CXCR4-transfected cells on VN and restores their migration on CG. uPAR co-expression also reduces the adherence of CXCR4-expressing cells to various components of the extracellular matrix (ECM) and influences the partitioning of beta1 and alpha-v integrins to membrane lipid-rafts, affecting ECM-dependent signaling. uPAR interference in CXCR4 activity has been confirmed in cells from prostate carcinoma. Our results demonstrate that uPAR expression regulates the adhesive and migratory ability of CXCR4-expressing cells through a mechanism involving fMLP receptors and alpha-v integrins. 相似文献
4.
5.
Riassunto Si può dimostrare un accumulo di H2O2 in leucociti polinucleati di essudato di cavia o di sangue umano durante la fagocitosi in presenza di KCN 2 mM. La produzione di H2O2 e l'attività della perossidasi si considerano importanti per l'azione battericida. 相似文献
6.
7.
Résumé Dans le foie de cobaye, l'activité du système enzymatique oxydasique des acides gras est renforcée par une faible oxydation
des acides succiniques et fumariques, tandis qu'elle est inhibée par une oxydation élevée. Il s'agit, peut-être, d'une concurrence
pour l'ADP ou bien pour les transporteurs d'hydrogène.
相似文献
8.
Summary Chronic administration of alcohol to well-nourished rats led to striking changes in the small intestinal cell population. The present experiments corroborate the view that alcohol is directly toxic to the small intestine.The authors wish to thank Mr.P. R. Gaspar for the technical assistance. 相似文献
9.
Christlieb N Bessell MS Beers TC Gustafsson B Korn A Barklem PS Karlsson T Mizuno-Wiedner M Rossi S 《Nature》2002,419(6910):904-906
The chemical composition of the most metal-deficient stars largely reflects the composition of the gas from which they formed. These old stars provide crucial clues to the star formation history and the synthesis of chemical elements in the early Universe. They are the local relics of epochs otherwise observable only at very high redshifts; if totally metal-free ('population III') stars could be found, this would allow the direct study of the pristine gas from the Big Bang. Earlier searches for such stars found none with an iron abundance less than 1/10,000 that of the Sun, leading to the suggestion that low-mass stars could form from clouds above a critical iron abundance. Here we report the discovery of a low-mass star with an iron abundance as low as 1/200,000 of the solar value. This discovery suggests that population III stars could still exist--that is, that the first generation of stars also contained long-lived low-mass objects. The previous failure to find them may be an observational selection effect. 相似文献
10.
G. Rossi V. Coiro L. Camellini D. Pignatti C. Davoli B. Lari R. Volpi P. Chiodera 《Cellular and molecular life sciences : CMLS》1985,41(12):1573-1574
Summary In order to establish whether thyrotropin-releasing hormone (TRH) inhibits lysine-vasopressin (LVP)-induced growth hormone (GH) release, six normal men were tested with LVP alone or in combination with TRH. LVP strikingly increased serum GH levels; this response was not altered by TRH. These results indicated that in man TRH is not involved in the control of GH secretion in response to LVP. 相似文献