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Reshaping human antibodies for therapy   总被引:76,自引:0,他引:76  
L Riechmann  M Clark  H Waldmann  G Winter 《Nature》1988,332(6162):323-327
A human IgGI antibody has been reshaped for serotherapy in humans by introducing the six hypervariable regions from the heavy- and light-chain variable domains of a rat antibody directed against human lymphocytes. The reshaped human antibody is as effective as the rat antibody in complement and is more effective in cell-mediated lysis of human lymphocytes.  相似文献   
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