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The aryl hydrocarbon receptor links TH17-cell-mediated autoimmunity to environmental toxins 总被引:3,自引:0,他引:3
Veldhoen M Hirota K Westendorf AM Buer J Dumoutier L Renauld JC Stockinger B 《Nature》2008,453(7191):106-109
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本文证明了公式β(n)=σ(n-1)+1其中α(n-1)是n-1次多项式微分系统的不为直线的最多条数,βn)是n次多项式微分系统的不变直线的不同斜率的最大个数。这里假设所讨论的多项式系统只有限条不变直线。 相似文献
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Daniela Barretto Barbosa Trivella José Ribamar Ferreira-Júnior Laure Dumoutier Jean-Christophe Renauld Igor Polikarpov 《Cellular and molecular life sciences : CMLS》2010,67(17):2909-2935
The IL-10 family of cytokines is comprised of IL-10, IL-19, IL-20, IL-22, IL-24, IL-26, and IFN-λs (IL-28A, IL-28B, and IL-29).
The IL-10 family members bind to shared class II cytokine receptor chains that associate in various combinations in heterodimeric
complexes. Upon interleukin/receptor complex formation, these proteins switch on the Jak/STAT pathway and elicit pleiotropic
biological responses whose variety sharply contrasts with their structural similarities. IL-10 family members are involved
in several human diseases and health conditions and hence their structural analyses may provide valuable information to design
specific therapeutic strategies. In this review, we describe the human interleukin-10 family of cytokines, focusing on their
structures and functions, with particular attention given to IL-22 and IL-10. We report on the recently published structures
of IL-10 cytokine family members and their complexes with cognate transmembrane and soluble receptors as well as on interleukin
physiology and physiopathology. 相似文献
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