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NLRP6 negatively regulates innate immunity and host defence against bacterial pathogens 总被引:1,自引:0,他引:1
PK Anand RK Malireddi JR Lukens P Vogel J Bertin M Lamkanfi TD Kanneganti 《Nature》2012,488(7411):389-393
Members of the intracellular nucleotide-binding and oligomerization domain (NOD)-like receptor (NLR) family contribute to immune responses through activation of nuclear factor-κB (NF-κB), type I interferon and inflammasome signalling. Mice lacking the NLR family member NLRP6 were recently shown to be susceptible to colitis and colorectal tumorigenesis, but the role of NLRP6 in microbial infections and the nature of the inflammatory signalling pathways regulated by NLRP6 remain unclear. Here we show that Nlrp6-deficient mice are highly resistant to infection with the bacterial pathogens Listeria monocytogenes, Salmonella typhimurium and Escherichia coli. Infected Nlrp6-deficient mice had increased numbers of monocytes and neutrophils in circulation, and NLRP6 signalling in both haematopoietic and radioresistant cells contributed to increased susceptibility. Nlrp6 deficiency enhanced activation of mitogen-activated protein kinase (MAPK) and the canonical NF-κB pathway after Toll-like receptor ligation, but not cytosolic NOD1/2 ligation, in vitro. Consequently, infected Nlrp6-deficient cells produced increased levels of NF-κB- and MAPK-dependent cytokines and chemokines. Thus, our results reveal NLRP6 as a negative regulator of inflammatory signalling, and demonstrate a role for this NLR in impeding clearance of both Gram-positive and -negative bacterial pathogens. 相似文献
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RobertK.Jadicke 《杭州科技》2000,21(3):3-4
美国硅谷的发展在整个世界引起了广泛的兴趣和关注 ,硅谷已成为美国高科技发展的标志 ,任何其他国家和地区的高科技的发展都不能和硅谷相比。经济论坛硅谷位于海湾和山谷之间 ,东西宽16公里 ,南北跨度50公里 ,并且正在不断延长。硅谷有4000家公司 ,他们都很小。80年代后期 ,IBM公司总裁访问了我大学 ,他告诉我硅谷3000多家公司中只有少于100家的年收入超过1亿美元。硅谷是从事信息技术的、小的、成长型公司的产地。直到硅半导体芯片运用于微电子工业 ,硅谷才成为美国乃至世界的高科技工业的中心。现在 ,许多大公司将生… 相似文献
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