排序方式: 共有19条查询结果,搜索用时 15 毫秒
1.
Active genes are tri-methylated at K4 of histone H3 总被引:92,自引:0,他引:92
Santos-Rosa H Schneider R Bannister AJ Sherriff J Bernstein BE Emre NC Schreiber SL Mellor J Kouzarides T 《Nature》2002,419(6905):407-411
Lysine methylation of histones in vivo occurs in three states: mono-, di- and tri-methyl. Histone H3 has been found to be di-methylated at lysine 4 (K4) in active euchromatic regions but not in silent heterochromatic sites. Here we show that the Saccharomyces cerevisiae Set1 protein can catalyse di- and tri-methylation of K4 and stimulate the activity of many genes. Using antibodies that discriminate between the di- and tri-methylated state of K4 we show that di-methylation occurs at both inactive and active euchromatic genes, whereas tri-methylation is present exclusively at active genes. It is therefore the presence of a tri-methylated K4 that defines an active state of gene expression. These findings establish the concept of methyl status as a determinant for gene activity and thus extend considerably the complexity of histone modifications. 相似文献
2.
3.
Organization and evolution of the class I gene family in the major histocompatibility complex of the C57BL/10 mouse 总被引:14,自引:0,他引:14
E H Weiss L Golden K Fahrner A L Mellor J J Devlin H Bullman H Tiddens H Bud R A Flavell 《Nature》1984,310(5979):650-655
The major histocompatibility complex (MHC) encodes several classes of protein vital to the regulation of the immune response. We have isolated 26 class I genes that map to this region in the C57BL/10 mouse and linked these into three gene clusters. The number of genes differs from the number found in the BALB/c strain and comparison of the organization of the class I genes in these two strains shows conserved regions and polymorphic regions which probably result from deletions, insertions and translocations within the MHC. 相似文献
4.
5.
6.
Expression of murine H-2Kb histocompatibility antigen in cells transformed with cloned H-2 genes 总被引:21,自引:0,他引:21
A L Mellor L Golden E Weiss H Bullman J Hurst E Simpson R F James A R Townsend P M Taylor W Schmidt J Ferluga L Leben M Santamaria G Atfield H Festenstein R A Flavell 《Nature》1982,298(5874):529-534
Cosmids containing H-2 histocompatibility antigen genes of the H-2b haplotype have been isolated. One of these genes expresses a 45,000 molecular weight protein, indistinguishable from H-2Kb when introduced into mouse L cells. These H-2Kb transformed L cells can be killed by allospecific anti-H-2Kb cytotoxic T cells. Moreover, when infected with influenza virus, they can be killed by an H-2Kb-restricted, influenza virus-specific cytotoxic T cell line. These results show that expression of the H-2Kb gene product on the L-cell surface is sufficient to make it a target for specific T-cell killing. 相似文献
7.
8.
Reverse transcriptase activity and Ty RNA are associated with virus-like particles in yeast 总被引:4,自引:0,他引:4
J Mellor M H Malim K Gull M F Tuite S McCready T Dibbayawan S M Kingsman A J Kingsman 《Nature》1985,318(6046):583-586
9.
10.
G Iordanidis P H Mellor D Holliday P M Churn 《中南大学学报(自然科学版)》2003,34(Z1):113-117
In this paper, a prototype direct-drive electro-mechanical actuator is proposed to select gears in a high performance gearbox. Because of the nonlinear behavior of the actuator, a fuzzy logic controller is adopted. The result of simulation has proved that the dynamic response obtained using the fuzzy controller is much faster than that obtained using traditional PD controller. 相似文献