Partial deficiency of erythrocyte spectrin in hereditary spherocytosis

Hereditary spherocytosis (HS) is a common, clinically heterogeneous haemolytic anaemia in which the primary erythrocyte defect is believed to be some abnormality in the spectrin-actin membrane skeleton, leading to loss of surface membrane. Recessively inherited spectrin deficiency with extreme erythrocyte fragility and spherocytosis has been identified in certain mutant mice and two severely anaemic humans. Although suspected, deficiency of spectrin has not been demonstrated in less severe forms of human HS. We not report the quantitation of erythrocytes spectrin by radioimmunoassay. We found that normal erythrocytes contained 240,000 copies of spectrin heterodimer, whereas erythrocytes from 14 patients with a variety of types of HS were all partially deficient in spectrin (range 74,000-200,000 copies), the magnitude of the deficiency correlating with the severity of the disease. Spectrin deficiency of varying degrees is common in HS and probably represents the principal structural defect leading to loss of surface membrane.     

Hormonal manipulation of carrageenin-induced pyresis in rats

Summary The intensity of the hyperthermic response in rats promoted by subplantar injection of 1 mg of carrageenin is directly related to the irritant properties of the type of carrageenin. The overall pyretic response is more dramatic in female rats than in male rats. Subtle changes in the time-course hyperthermic profiles are seen after hormonal modifications.This work was supported by NIH, MBS research grant No. RR08111.     

Daily volatility forecasts: reassessing the performance of GARCH models

Volatility plays a key role in asset and portfolio management and derivatives pricing. As such, accurate measures and good forecasts of volatility are crucial for the implementation and evaluation of asset and derivative pricing models in addition to trading and hedging strategies. However, whilst GARCH models are able to capture the observed clustering effect in asset price volatility in‐sample, they appear to provide relatively poor out‐of‐sample forecasts. Recent research has suggested that this relative failure of GARCH models arises not from a failure of the model but a failure to specify correctly the ‘true volatility’ measure against which forecasting performance is measured. It is argued that the standard approach of using ex post daily squared returns as the measure of ‘true volatility’ includes a large noisy component. An alternative measure for ‘true volatility’ has therefore been suggested, based upon the cumulative squared returns from intra‐day data. This paper implements that technique and reports that, in a dataset of 17 daily exchange rate series, the GARCH model outperforms smoothing and moving average techniques which have been previously identified as providing superior volatility forecasts. Copyright © 2004 John Wiley & Sons, Ltd.     

Formation of massive black holes through runaway collisions in dense young star clusters

A luminous X-ray source is associated with MGG 11--a cluster of young stars approximately 200 pc from the centre of the starburst galaxy M 82 (refs 1, 2). The properties of this source are best explained by invoking a black hole with a mass of at least 350 solar masses (350 M(o)), which is intermediate between stellar-mass and supermassive black holes. A nearby but somewhat more massive cluster (MGG 9) shows no evidence of such an intermediate-mass black hole, raising the issue of just what physical characteristics of the clusters can account for this difference. Here we report numerical simulations of the evolution and motion of stars within the clusters, where stars are allowed to merge with each other. We find that for MGG 11 dynamical friction leads to the massive stars sinking rapidly to the centre of the cluster, where they participate in a runaway collision. This produces a star of 800-3,000 M(o) which ultimately collapses to a black hole of intermediate mass. No such runaway occurs in the cluster MGG 9, because the larger cluster radius leads to a mass segregation timescale a factor of five longer than for MGG 11.     

Pressure-induced amorphization and an amorphous-amorphous transition in densified porous silicon.

Crystalline and amorphous forms of silicon are the principal materials used for solid-state electronics and photovoltaics technologies. Silicon is therefore a well-studied material, although new structures and properties are still being discovered. Compression of bulk silicon, which is tetrahedrally coordinated at atmospheric pressure, results in a transition to octahedrally coordinated metallic phases. In compressed nanocrystalline Si particles, the initial diamond structure persists to higher pressure than for bulk material, before transforming to high-density crystals. Here we report compression experiments on films of porous Si, which contains nanometre-sized domains of diamond-structured material. At pressures larger than 10 GPa we observed pressure-induced amorphization. Furthermore, we find from Raman spectroscopy measurements that the high-density amorphous form obtained by this process transforms to low-density amorphous silicon upon decompression. This amorphous-amorphous transition is remarkably similar to that reported previously for water, which suggests an underlying transition between a high-density and a low-density liquid phase in supercooled Si (refs 10, 14, 15). The Si melting temperature decreases with increasing pressure, and the crystalline semiconductor melts to a metallic liquid with average coordination approximately 5 (ref. 16).     

Subspecific origin and haplotype diversity in the laboratory mouse

Here we provide a genome-wide, high-resolution map of the phylogenetic origin of the genome of most extant laboratory mouse inbred strains. Our analysis is based on the genotypes of wild-caught mice from three subspecies of Mus musculus. We show that classical laboratory strains are derived from a few fancy mice with limited haplotype diversity. Their genomes are overwhelmingly Mus musculus domesticus in origin, and the remainder is mostly of Japanese origin. We generated genome-wide haplotype maps based on identity by descent from fancy mice and show that classical inbred strains have limited and non-randomly distributed genetic diversity. In contrast, wild-derived laboratory strains represent a broad sampling of diversity within M. musculus. Intersubspecific introgression is pervasive in these strains, and contamination by laboratory stocks has played a role in this process. The subspecific origin, haplotype diversity and identity by descent maps can be visualized using the Mouse Phylogeny Viewer (see URLs).     

Forecasting Stock Returns: Do Commodity Prices Help?

This paper examines the relationship between stock prices and commodity prices and whether this can be used to forecast stock returns. As both prices are linked to expected future economic performance they should exhibit a long‐run relationship. Moreover, changes in sentiment towards commodity investing may affect the nature of the response to disequilibrium. Results support cointegration between stock and commodity prices, while Bai–Perron tests identify breaks in the forecast regression. Forecasts are computed using a standard fixed (static) in‐sample/out‐of‐sample approach and by both recursive and rolling regressions, which incorporate the effects of changing forecast parameter values. A range of model specifications and forecast metrics are used. The historical mean model outperforms the forecast models in both the static and recursive approaches. However, in the rolling forecasts, those models that incorporate information from the long‐run stock price/commodity price relationship outperform both the historical mean and other forecast models. Of note, the historical mean still performs relatively well compared to standard forecast models that include the dividend yield and short‐term interest rates but not the stock/commodity price ratio. Copyright © 2014 John Wiley & Sons, Ltd.     

塔板式鼓泡塔的流体力学特性

研究了φ７ｃｍ金属丝网塔板（ａ＝０．６４）鼓泡塔的流体力学特性，气速和液速的变化范围分别为：０＜ｖｇ＜８ｃｍ／ｓ，０．３＜Ｖ１＜３．３ｃｍ／ｓ，塔内金属丝网析数为０～３７． 丝网塔板的应用有效地限制了气泡合并，并使气泡大小及分布均匀，气含率及相际面积均大为增加。但塔板的应用增加了鼓泡塔中的阻力降，其值可由分离流动摸型或由测定液相内循环速率及单相流动阻力系数得到。丝网塔板大大减小了鼓泡塔的液相返混，其流动接近于活塞流．