承载供应链管理的客户关系链管理分析与建模

指出了客户关系管理的概念不足,以实际例子引出客户关系链的概念,并分析指出客户关系链可以承载供应链的运作管理.利用Markov链对该过程建模,对简单的情况进行了分析和计算,并给出了如果忽略了客户下游信息,企业所受到的损失分析.并同供应链系统作了类比.     

一个用于中小型企业的扩展ERP软件流程集成模型分析

在以前工作的基础上,主要讨论了一个将ERP(enterpriseresourceplanning,企业资源规划)、SRM(supplierrelationshipmanagement,供应商关系管理)、CRM(customerrelationshipmanagement,客户关系管理)集成为一体的简化流程模型.论文在界定了几个基本概念的基础上,描述了接触中心的发出流程和接收流程功能,讨论了对ERP软件的流程及核心管理和CRM软件的流程及核心管理思路,研究了对ERP同CRM的关联点,仿照对CRM的分析,对SRM做了类似的分析,最后给出了以关系为企业围墙的扩展ERP简化模型.     

A viral microRNA functions as an orthologue of cellular miR-155

All metazoan eukaryotes express microRNAs (miRNAs), roughly 22-nucleotide regulatory RNAs that can repress the expression of messenger RNAs bearing complementary sequences. Several DNA viruses also express miRNAs in infected cells, suggesting a role in viral replication and pathogenesis. Although specific viral miRNAs have been shown to autoregulate viral mRNAs or downregulate cellular mRNAs, the function of most viral miRNAs remains unknown. Here we report that the miR-K12-11 miRNA encoded by Kaposi's-sarcoma-associated herpes virus (KSHV) shows significant homology to cellular miR-155, including the entire miRNA 'seed' region. Using a range of assays, we show that expression of physiological levels of miR-K12-11 or miR-155 results in the downregulation of an extensive set of common mRNA targets, including genes with known roles in cell growth regulation. Our findings indicate that viral miR-K12-11 functions as an orthologue of cellular miR-155 and probably evolved to exploit a pre-existing gene regulatory pathway in B cells. Moreover, the known aetiological role of miR-155 in B-cell transformation suggests that miR-K12-11 may contribute to the induction of KSHV-positive B-cell tumours in infected patients.