Prediction of Absorption Enthalpy from Solubility Data for the MDEA-H_2O-CO_2 System

IntroductionThe absorption of CO2 by a solution of methyldiethanol amine ( MDEA) and H2 O is widely usedfor decarbonization processes in the syntheticammonia industry. This solution has advantages ofgood absorbency,low energy consumption,andlow degree deg…     

Separation of Organic Dyes from Water by Colloidal Gas Aphrons

IntroductionColloidal gas aphrons ( CGAs) are dispersions ofvery small microbubbles( usually of diameters inthe range of2 5 1 2 5 μm) distributed in an aqueousmedium. Sebba[1] first reported colloidal gasaphrons in 1 971 . Colloidal gas aphrons are gasbu…     

A synthetic homing endonuclease-based gene drive system in the human malaria mosquito

Genetic methods of manipulating or eradicating disease vector populations have long been discussed as an attractive alternative to existing control measures because of their potential advantages in terms of effectiveness and species specificity. The development of genetically engineered malaria-resistant mosquitoes has shown, as a proof of principle, the possibility of targeting the mosquito's ability to serve as a disease vector. The translation of these achievements into control measures requires an effective technology to spread a genetic modification from laboratory mosquitoes to field populations. We have suggested previously that homing endonuclease genes (HEGs), a class of simple selfish genetic elements, could be exploited for this purpose. Here we demonstrate that a synthetic genetic element, consisting of mosquito regulatory regions and the homing endonuclease gene I-SceI, can substantially increase its transmission to the progeny in transgenic mosquitoes of the human malaria vector Anopheles gambiae. We show that the I-SceI element is able to invade receptive mosquito cage populations rapidly, validating mathematical models for the transmission dynamics of HEGs. Molecular analyses confirm that expression of I-SceI in the male germline induces high rates of site-specific chromosomal cleavage and gene conversion, which results in the gain of the I-SceI gene, and underlies the observed genetic drive. These findings demonstrate a new mechanism by which genetic control measures can be implemented. Our results also show in principle how sequence-specific genetic drive elements like HEGs could be used to take the step from the genetic engineering of individuals to the genetic engineering of populations.