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Hobmayer B Rentzsch F Kuhn K Happel CM von Laue CC Snyder P Rothbächer U Holstein TW 《Nature》2000,407(6801):186-189
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Unexpected complexity of the Wnt gene family in a sea anemone 总被引:1,自引:0,他引:1
Kusserow A Pang K Sturm C Hrouda M Lentfer J Schmidt HA Technau U von Haeseler A Hobmayer B Martindale MQ Holstein TW 《Nature》2005,433(7022):156-160
The Wnt gene family encodes secreted signalling molecules that control cell fate in animal development and human diseases. Despite its significance, the evolution of this metazoan-specific protein family is unclear. In vertebrates, twelve Wnt subfamilies were defined, of which only six have counterparts in Ecdysozoa (for example, Drosophila and Caenorhabditis). Here, we report the isolation of twelve Wnt genes from the sea anemone Nematostella vectensis, a species representing the basal group within cnidarians. Cnidarians are diploblastic animals and the sister-group to bilaterian metazoans. Phylogenetic analyses of N. vectensis Wnt genes reveal a thus far unpredicted ancestral diversity within the Wnt family. Cnidarians and bilaterians have at least eleven of the twelve known Wnt gene subfamilies in common; five subfamilies appear to be lost in the protostome lineage. Expression patterns of Wnt genes during N. vectensis embryogenesis indicate distinct roles of Wnts in gastrulation, resulting in serial overlapping expression domains along the primary axis of the planula larva. This unexpectedly complex inventory of Wnt family signalling factors evolved in early multi-cellular animals about 650 million years (Myr) ago, predating the Cambrian explosion by at least 100 Myr (refs 5, 8). It emphasizes the crucial function of Wnt genes in the diversification of eumetazoan body plans. 相似文献
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W. C. Quevedo Jr. Theresa C. Bienieki T. J. Holstein H. J. Dyer 《Cellular and molecular life sciences : CMLS》1975,31(9):1034-1036
Summary Five isozymes of LDH are demonstrable in the epidermis of the ear pinnae, hind feet, trunk dorsa, and tails of adult C57BL,
C57HR, and C3HB mice by polyacrylamide gel electrophoresis. LDH-5 activity predominates in electropherograms. The ratio of
LDH-1 to LDH-5 is greater in the epidermis of ear pinna and trunk dorsum than in that of tail and hind foot. The region-specific
patterns of epidermal LDH isozymes are not correlated with melanin pigmentation or ‘hairiness’ of the skin.
Supported by PHS Research Grant No. CA-06097 from the National Cancer Institute, United States Public Health Service. 相似文献
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Five isozymes of LDH are demonstrable in the epidermis of the ear pinnae, hind feet, trunk dorsa, and tails of adult C57BL, C57HR, and C3HB mice by polyacrylamide gel electrophoresis. LDH-5 activity predominates in electropherograms. The ratio of LDH-1 to LDH-K is greater in the epidermis of ear pinna and trunk dorsum than in that of tail and hind foot. The region-specific patterns of epidermal LDH isozymes are not correlated with melanin pigmentation or "hairiness' of the skin. 相似文献
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