软岩注浆预加固技术在公路隧道中的应用

文章对软岩的结构特征与分类、注浆加固机理进行了介绍,对公路隧道软岩施工中的超前小导管注浆加固技术,从加固机理、注浆必要性、施工工艺等方面作了阐述.     

DPOAE信号时域分解算法的窗宽选择

研究畸变产物耳声发射(DPOAE)产生源机制常用分解方法,针对实验分解方法干扰多、实验量大的特点,该文提出基于小波分解的互相关和基于DPOAE时域能量分布的窗宽选择算法进行时域分解.通过强化不同成分分界点,加窗提取相位特征不同的信号成分.结果与实验方法进行对比,表明算法实现了DPOAE的准确分解,其效果与实验加最佳抑制声时结果相似,同时避免了干扰、减少了实验量.该方法为DPOAE产生源机制的研究提供了更方便、准确的研究工具.     

关于我国网络银行发展的思考

文章从网络银行的优势入手,分析了网络银行在我国的发展现状,提出了从控制风险、市场定位、服务特点和发展模式发展网络银行的观点.     

Cells compete for decapentaplegic survival factor to prevent apoptosis in Drosophila wing development

During the growth of Drosophila imaginal discs a process called 'cell competition' eliminates slow-proliferating but otherwise viable cells. We report here that cell competition requires the function of the brinker (brk) gene, whose expression is normally repressed by Decapentaplegic (Dpp) signalling but is upregulated in slow-growing Minute/+ cells. Excess brk expression activates the c-Jun amino-terminal kinase pathway, which in turn triggers apoptosis in these cells. We propose that slow-proliferating cells upregulate Brk levels owing to a disadvantage in competing for, or in transducing, the Dpp survival signal. This sequence of events might represent a general mechanism by which weaker cells are eliminated from a growing population, and might serve as a method of controlling cell number and optimizing tissue fitness and hence organ function.     

新的H2O脉泽源的发现与证认

用紫金山天文台青海站的１３．７ｍ射电望远镜对一批强ＩＲＡＳ远红外源进行了Ｈ２Ｏ脉泽谱线的搜寻，发现了１０个新的Ｈ２Ｏ脉泽源。其中９个源均与恒星形成区成协，它们是正在形成中的大质量星的标志，另一个则是著名的富碳星ＩＲＣ１０２１６，在富碳星包层中Ｈ２Ｏ脉泽活动的出现是罕见的。还讨论了这些新发现源的演化特性和时变特性。     

Chemical glycosylation in the synthesis of glycoconjugate antitumour vaccines

Therapeutic vaccines derived from carbohydrate antigen-adjuvant combinations are a promising approach for cancer immunotherapy. One of the critical limitations in this area is access to sufficient quantities of tumour-associated carbohydrate antigens and glycoconjugate adjuvants. At present, availability of the complex oligosaccharide constructs that are needed for the systematic design and evaluation of novel vaccine formulations relies on de novo chemical synthesis. The use of both state-of-the-art and emerging glycosylation technologies has led to significant advances in this field, allowing the clinical exploration of carbohydrate-based antigens in the treatment of cancer.     

Exome sequencing identifies recurrent mutations of the splicing factor SF3B1 gene in chronic lymphocytic leukemia

Here we perform whole-exome sequencing of samples from 105 individuals with chronic lymphocytic leukemia (CLL), the most frequent leukemia in adults in Western countries. We found 1,246 somatic mutations potentially affecting gene function and identified 78 genes with predicted functional alterations in more than one tumor sample. Among these genes, SF3B1, encoding a subunit of the spliceosomal U2 small nuclear ribonucleoprotein (snRNP), is somatically mutated in 9.7% of affected individuals. Further analysis in 279 individuals with CLL showed that SF3B1 mutations were associated with faster disease progression and poor overall survival. This work provides the first comprehensive catalog of somatic mutations in CLL with relevant clinical correlates and defines a large set of new genes that may drive the development of this common form of leukemia. The results reinforce the idea that targeting several well-known genetic pathways, including mRNA splicing, could be useful in the treatment of CLL and other malignancies.     

几何—算术平均不等式的两种归纳证明

对几何—算术平均不等式给出两种初等的归纳证明。     

Systems of Logical Systems: Neuroscience and Quantum Logic

Nervous systems are intricately organized on many levels of analysis.The intricate organization invites the development of mathematicalsystems that reflect its logical structure. Particular logical structures and choices of invariants within those structures narrowthe ranges of perceptions that are possible and sensorimotorcoordination that may be selected. As in quantum logic, choicesaffect outcomes. Some of the mathematical tools in use in quantum logic havealready also been used in neurobiology, including the mathematicsof ordered structures and a product like a tensor product. Astheoretical neurobiology is developed on its own foundation, wemay expect a rich dialogue between theoretical neurobiology andquantum logic.