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A. Gutnisky P. Glikman M. F. Gimeno A. L. Gimeno 《Cellular and molecular life sciences : CMLS》1982,38(1):116-117
Summary The administration of 15(R)-15-methyl prostaglandin E2 (15(R)-15-M-PGE2) in vivo significantly diminished the uptake of59Fe into blood, spleen, liver, femur and dried intestine of rats, whereas acetylsalicylic acid (ASA) increased the counts significantly. This effect of ASA was counteracted by 15(R)-15-M-PGE2. It is suggested that prostaglandins (PGs) might play an important role in inhibiting iron absorption at the intestinal level.This work was supported by grant No.6638 from CONICET (Argentina). The technical assistance of Mrs María E. Castro and Norma Rizzo is gratefully acknowleged. 相似文献
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E. A. Savino M. F. Gimeno A. L. Gimeno 《Cellular and molecular life sciences : CMLS》1967,23(2):144-145
Zusammenfassung Oxamat, das die Lactat-Dehydrogenase hemmt, erniedrigt die Kontraktionsfähigkeit des Vorhofs mit und ohne Anwesenheit von Glucose im Medium und bei Hinzufügung von 2-DG oder Atropin. Hohe Konzentration von Pyruvat erhöht die Depression von Oxamat auf den Vorhof im Glucose-Milieu. Oxamat sensibilisiert das Gewebe für funktionellen Abbau durch Glycolyse.
This research was supported by grants No. 1441 and No. HE-994801 from Consejo Nacional de Investigaciones de la República Argentina, and from the National Institute of Health, respectively.
Research Fellow from the Consejo Nacional de Investigaciones de la República Argentina.
Established Investigator from the Consejo Nacional de Investigaciones de la República Argentina. 相似文献
This research was supported by grants No. 1441 and No. HE-994801 from Consejo Nacional de Investigaciones de la República Argentina, and from the National Institute of Health, respectively.
Research Fellow from the Consejo Nacional de Investigaciones de la República Argentina.
Established Investigator from the Consejo Nacional de Investigaciones de la República Argentina. 相似文献
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P. Glikman A. Gutnisky M. F. Gimeno A. L. Gimeno 《Cellular and molecular life sciences : CMLS》1981,37(6):589-590
Summary The in vivo administration of59Fe to the rat accompanied by acetylsalicylic acid (ASA) enhanced significantly counts in blood, spleen, liver and femur without affecting those of the intestine. The results suggest that ASA augments iron absorption either via an inhibitory action on the synthesis of prostaglandins or by a purely chemical mechanism.This work was supported by Grant No. 6638 from CONICET (Argentina).The technical assistance of Mrs María E. Castro and Mrs Patricia Dubra is gratefully acknowledged. 相似文献
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Arsenite but not oxamate produce in vitro a distinct depression of estrogen-dominated uterine motility, both in the absence of substrate as well as in the presence of exogenous glucose or lactate. The addition of oxamate to preparations suspended in a medium with lactate as the sole external substrate ameliorates the depression of uterine motility elicited by arsenic. 相似文献
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The effects of prostacyclin (PGI2) on the contractile frequency and on the isometric developed tension of spontaneously beating or paced isolated rat atria were explored. PGI2 enhanced frequency and contractile tension, both effects being blocked by the presence of propranolol, or following a pretreatment with 6-OHDopamine. 相似文献
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A. L. Gimeno A. Goldraij M. F. Gimeno 《Cellular and molecular life sciences : CMLS》1979,35(2):221-222
Summary Arsenite but not oxamate produce in vitro a distinct depression of estrogen-dominated uterine motility, both in the absence of substrate as well as in the presence of exogenous glucose or lactate. The addition of oxamate to preparations suspended in a medium with lactate as the sole external substrate ameliorates the depression of uterine motility elicited by arsenite.This work has been supported by grants 6638 and 6294 from the Consejo Nacional de Investigaciones Cientificas y Técnicas de la República Argentina.Senior Investigator of the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina.Junior Investigator of the Consejo Nacional de Investigaciones Científicas y Técnicas de la República Argentina. 相似文献
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Is prostacyclin subserving a vasodilator effect of methoxamine involving alpha adrenoreceptors? 总被引:1,自引:0,他引:1
The influence of methoxamine on the contractile tension of isolated rat abdominal aorta, and on its capacity to produce a platelet antiaggregating substance, were explored. Methoxamine stimulated platelet antiaggregation and diminished arterial tone. The last action was blocked by phentolamine as well as by inhibitors of cyclo-oxygenase and prostacyclinsynthetase. 相似文献
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