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Coles P  Chiang LY 《Nature》2000,406(6794):376-378
The local Universe displays a rich hierarchical pattern of galaxy clusters and superclusters. The early Universe, however, was almost smooth, with only slight 'ripples' as seen in the cosmic microwave background radiation. Models of the evolution of cosmic structure link these observations through the effect of gravity, because the small initially overdense fluctuations are predicted to attract additional mass as the Universe expands. During the early stages of this expansion, the ripples evolve independently, like linear waves on the surface of deep water. As the structures grow in mass, they interact with each other in nonlinear ways, more like waves breaking in shallow water. We have recently shown how cosmic structure can be characterized by phase correlations associated with these nonlinear interactions, but it was not clear how to use that information to obtain quantitative insights into the growth of structures. Here we report a method of revealing phase information, and show quantitatively how this relates to the formation of filaments, sheets and clusters of galaxies by nonlinear collapse. We develop a statistical method based on information entropy to separate linear from nonlinear effects, and thereby are able to disentangle those aspects of galaxy clustering that arise from initial conditions (the ripples) from the subsequent dynamical evolution.  相似文献   
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H Marrero  M L Astion  J A Coles  R K Orkand 《Nature》1989,339(6223):378-380
The functions of glial cells in the nervous system are not well defined, with the exception of myelin production by oligodendrocytes, uptake of amino-acid synaptic transmitters, and a contribution to extracellular potassium homeostasis. Neuroglia have receptors for neurotransmitters which may be involved in neuron-glia interactions. Recent studies have demonstrated voltage-gated ion channels in glial membranes. In a study of the optic nerve of the frog, small areas of the surface were examined with the loose patch-clamp method, and voltage-gated Na+ and K+ channels, presumably located in the membranes of the astrocytes forming the glia limitans, were identified. We now report that nerve impulses in the axons of the frog optic nerve transiently alter the properties of the voltage-dependent membrane channels of the surface glial cells (astrocytes), a demonstration of a new form of neuron-glia interaction.  相似文献   
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The mode of action of four anthelmintics   总被引:2,自引:0,他引:2  
G C Coles  J M East  S M Jenkins 《Experientia》1974,30(11):1265-1266
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Résumé LesAscaris qui se sont «déparalysés» après une incubation prolongée dans 100 ppm de levamisole, ne se contractent pas après injection des anthélminitiques béphenium, méthyridine et pyrantel. Etant donné que la mécamyline et la pempidine bloquent les contractions desAscaris provoquées par le levamisole, il paraît probable que chez les Nématodes ces 4 anthélmintiques sont des stimulateurs des ganglions.  相似文献   
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本文较深入地研究了脱硫石膏粉煤灰化学成分、杂质、颗粒特征和激发剂等对脱硫石膏、粉煤灰胶结材性能的影响 研究表明 ,激发剂是影响脱硫石膏、粉煤灰胶结材性能的主要因素 这为脱硫石膏、粉煤灰资源化利用打下良好理论基础 经实际应用表明 ,研究结果与实际情况能很好相符  相似文献   
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Coles P 《Nature》1990,344(6261):7
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Attention is drawn to a clear statement of the concept of an absolute zero of temperature by John Locke some time between 1698 and 1704. From the writings of Boyle and Newton it seems unlikely that either of them was responsible for providing their friend with this insight.  相似文献   
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