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Genome sequence and analysis of the tuber crop potato 总被引:11,自引:0,他引:11
Potato Genome Sequencing Consortium Xu X Pan S Cheng S Zhang B Mu D Ni P Zhang G Yang S Li R Wang J Orjeda G Guzman F Torres M Lozano R Ponce O Martinez D De la Cruz G Chakrabarti SK Patil VU Skryabin KG Kuznetsov BB Ravin NV Kolganova TV Beletsky AV Mardanov AV Di Genova A Bolser DM Martin DM Li G Yang Y Kuang H Hu Q Xiong X Bishop GJ Sagredo B Mejía N Zagorski W Gromadka R Gawor J Szczesny P Huang S Zhang Z Liang C He J Li Y He Y Xu J Zhang Y Xie B Du Y Qu D Bonierbale M Ghislain M 《Nature》2011,475(7355):189-195
Potato (Solanum tuberosum L.) is the world's most important non-grain food crop and is central to global food security. It is clonally propagated, highly heterozygous, autotetraploid, and suffers acute inbreeding depression. Here we use a homozygous doubled-monoploid potato clone to sequence and assemble 86% of the 844-megabase genome. We predict 39,031 protein-coding genes and present evidence for at least two genome duplication events indicative of a palaeopolyploid origin. As the first genome sequence of an asterid, the potato genome reveals 2,642 genes specific to this large angiosperm clade. We also sequenced a heterozygous diploid clone and show that gene presence/absence variants and other potentially deleterious mutations occur frequently and are a likely cause of inbreeding depression. Gene family expansion, tissue-specific expression and recruitment of genes to new pathways contributed to the evolution of tuber development. The potato genome sequence provides a platform for genetic improvement of this vital crop. 相似文献
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Moshnikova AB Afanasyev VN Proussakova OV Chernyshov S Gogvadze V Beletsky IP 《Cellular and molecular life sciences : CMLS》2006,63(2):229-234
Currently, chemical bifunctional cross-linkers are regarded as promising therapeutic agents capable of affecting cell metabolism.
Depending on the nature of the active groups and on the length of their mediating spacer, these cross-linkers have been shown
to influence mitochondrial functions, the cell cycle and cell death. The current study was aimed to assay cellular effects
of a cross-linker with ‘zero’-length spacer, 1-ethyl-3-(3-dimethylaminopropyl)-carbodiimide (EDC). When added to cultures
of transformed cells, EDC induced a G2/M blockade followed by cell death. Analysis of the molecular targets revealed that
alteration of the cell cycle was caused by EDC-induced interchain cross-linking within double-stranded DNA. Administration
of EDC to animals with experimental tumors increased their life span. The analysis of tumor cells from EDC-treated mice showed
up-regulation of p21/WAF1, disturbance of tumor cell cytokinesis and, hence, cell death. Thus, both in vitro and in vivo, EDC exhibits cytotoxic activity, which may be of potential therapeutic use.
Received 15 August 2005; received after revision 23 September 2005; accepted 15 November 2005 相似文献
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Alexander V. Kolobov a) onleavefromA .F .IoffePhysico TechnicalInstitute StPetersburg Russia 《中国科学技术大学学报》2001,31(3):282-288
Thelatticemismatchbetweenthesubstrateandtheovergrownlayerallowstheformationofself as sembledquantumdots (QDs)throughtheStranski Krastanovmechanism[1,2 ] .Thistechniquehasbeensuccessfullyappliedtovarioussemiconductorsystems,andinparticulartoGe/Siquantumdots(Q… 相似文献
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