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Rapid renewal of auditory hair bundles 总被引:14,自引:0,他引:14
Stereocilia, also known as hair bundles, are mechanosensitive organelles of the sensory hair cells of the inner ear that can detect displacements on a nanometre scale and are supported by a rigid, dense core of actin filaments. Here we show that these actin-filament arrays are continuously remodelled by the addition of actin monomers to the stereocilium tips, and that the entire core of the stereocilium is renewed every 48 hours. This unexpected dynamic feature of stereocilia will help our understanding of how auditory sensory function develops and is maintained. 相似文献
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H. M. L. de Souza I. R. Baracho C. L. Messias J. L. de Azevedo 《Cellular and molecular life sciences : CMLS》1977,33(11):1433-1434
Summary Wild-type strains and auxotrophic mutants ofAspergillus flavus, differing regarding aflatoxin production, were tested for esterases isozymes. Esterases variation was found in all strains used, and a possible correlation between the pattern of esterase bands and aflatoxin production is suggested.Acknowledgment. The authors are thankful to the National Council for the development of Science and Technology (CNPq) and Assistance to Research for São Paulo State (FAPESP) for financial assistance. 相似文献
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E. de Conti C. L. Messias Hebe Myrina L. de Souza J. L. Azevedo 《Cellular and molecular life sciences : CMLS》1980,36(3):293-294
Summary 11 wild-type strains ofMetarrhizium anisopliae were electrophoretically tested for phosphatases and esterases. Phosphatase was homogeneous for all strains. For esterase it was possible to distinguish 5 different patterns with which it is possible to characterize the strains analyzed.Acknowledgment. The authors are thankful to the Conselho Nacional de Desenvolvimento Cientifico e Tecnológico (CNPq) and to the Empresa Brasileira de Pesquisa Agropecuária (EM-BRAPA) for financial assistance. 相似文献
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The mutational deterministic hypothesis for the origin and maintenance of sexual reproduction posits that sex enhances the ability of natural selection to purge deleterious mutations after recombination brings them together into single genomes. This explanation requires negative epistasis, a type of genetic interaction where mutations are more harmful in combination than expected from their separate effects. The conceptual appeal of the mutational deterministic hypothesis has been offset by our inability to identify the mechanistic and evolutionary bases of negative epistasis. Here we show that negative epistasis can evolve as a consequence of sexual reproduction itself. Using an artificial gene network model, we find that recombination between gene networks imposes selection for genetic robustness, and that negative epistasis evolves as a by-product of this selection. Our results suggest that sexual reproduction selects for conditions that favour its own maintenance, a case of evolution forging its own path. 相似文献
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David R Myers Kan Bun Cheng Babak Jamshidi Robert G Azevedo Debbie G Senesky Li Chen Mehran Mehregany Muthu B J Wijesundar Albert P Pisano 《中国工程科学》2012,10(5):36-41
We present the fabrication and testing of a silicon carbide(SiC)balanced mass double-ended tuning fork that survives harsh environments without compromising the device strain sensitivity and resolution bandwidth.The device features a material stack that survives corrosive environments and enables high-temperature operation.To perform high-temperature testing,a specialized setup was constructed that allows the tuning fork to be characterized using traditional silicon electronics.The tuning fork has been operated at 600 ℃ in the presence of dry steam for short durations.This tuning fork has also been tested to 64 000 G using a hard-launch,soft-catch shock implemented with a light gas gun.However,the device still has a strain sensitivity of 66 Hz/με and strain resolution of 0.045 με in a 10 kHz bandwidth.As such,this balanced-mass double-ended tuning fork can be used to create a variety of different sensors including strain gauges,accelerometers,gyroscopes,and pressure transducers.Given the adaptable fabrication process flow,this device could be useful to micro-electro-mechanical systems(MEMS) designers creating sensors for a variety of different applications. 相似文献
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Celso O. Azevedo Simon van Noort David G. Notton 《Journal of Natural History》2018,52(23-24):1537-1549
Holepyris semiruber Kieffer is redescribed and illustrated based on freshly collected specimens. Holepyris semiruber var. striatipleura Kieffer is considered a colour variant of this species and therefore a junior synonym of H. semiruber syn. nov. This species is transferred to Disepyris, D. semiruber (Kieffer) comb. nov., based on the possession of a short 2r-rs&Rs vein in the fore wing and presence of long flat spine-shaped setae on the outer (posterior) surface of the protarsi. The male is described for the first time from new specimens collected in South Africa. This species is recorded for the first time from Namibia and Zimbabwe. All photographs are available on www.waspweb.org. 相似文献
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