Tussah Silk Fibroin Porous Scaffolds Prepared with a Mild Self-assembly Process for Controlled Drug Release

Besides excellent biodegradability and biocompatibility,a useful tissue engineering scaffold should provide favorable surface properties,outstanding mechanical strength and controlled drug release property. In this paper,a mild process to prepare porous tussah silk fibroin（ TSF） scaffolds from aqueous solution was described. The n-butanol was used to control the self-assembly of tussah silk. The scaffolds with different TSF concentrations and the same volume showed differences in pore size and distribution. The maximum porosity of the poprepared porous scaffolds was 80% in this paper. And the pore size of the prepared porous scaffolds with different concentrations was between 10μm and 230 μm. X-ray diffraction（ XRD） analysis revealed that amorphous TSF was crystallized to β-sheet secondary structure upon gelatin. The TSF scaffolds for controlled drug release was studied and the result showed that the time of drug release was significantly longer. The produced TSF scaffolds with sustained drug release have potential application in tissue engineering.     

柔性多层隔热膜温度的对称与非对称梯度衰减

提出了柔性多层隔热膜的理想传热模型,并理论计算了柔性多层隔热膜温度的对称梯度衰减与非对称梯度衰减.在对称梯度衰减中,给定最外层与最内层温度及层数,通过Matlab用牛顿迭代法数值计算多层隔热膜只有辐射换热、连续固体导热与两种传热方式综合时的温度分布.非对称梯度衰减中,通过理论计算了隔绝200℃与一-20%,所需的柔性隔热膜的层数及每层的温度分布.并通过对比,得出适合本文柔性多层膜隔热的理论计算方法.     

多孔柞蚕丝素支架的制备及其在药物缓释中的应用

采用冷冻干燥法制备了多孔柞蚕丝素支架,分析了丝素溶液浓度与支架孔径、孔隙率之间的关系,并研究了多孔柞蚕丝素支架负载5-氟尿嘧啶的缓释性能.研究表明,当丝素浓度较低时,支架中的孔洞分布较为均匀,孔径和孔隙率也较大,而随着丝素溶液浓度增大,支架的孔径和孔隙率逐渐减小;支架的药物释放过程可分为快速释放和缓慢释放两个阶段.