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IntroductionThe progression of a tumor cell from benigndelimited proliferation to malignant and metastaticgrowth is the majorcause of poorclinical outcomesof cancer therapy.Angiogenesis in the host is acharacteristic phenomenon of most malignanttumors.With adequate blood supply,tumor cellswill not only grow,but also acquire metastaticpotential[1] . This process may involve theproduction of tumor- derived mediators ofendothelial cell migration and proliferation throughenzymes ( such as collagen… 相似文献
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