TGF-β1和bFGF在肺泡间隔 胶原沉积中的作用

The objective is to study the action of transforming growth factor-β₁(TGF-β₁)and basic fibroblast growth factor(bFGF)in the collagen deposition of fibrotic interstitial lung desease(FILD)by using the methods of HE staining and Masson's trichrome staining and the inmmunohistochemical SP method.Collagen was singularly deposited in alveolar septum when FILD developed into the late stage.Abnormal collagen deposition in alveolar septum has four grades.It was demonstrated that the positive\|rates of TGF-β₁ expressed both in pulmonary macrophages and hyperplasia pneumocytes type　Ⅱ of FILD cases were higher than those of diseas control cases,and there was a significant difference between the two groups(P＜0.05).However,only the positive\|rates of TGF-β₁ expressed in hyperplasia pneumocytes type Ⅱ of collagen\|deposited cases were higher than those of no collagen\|deposited cases(P=0.01),both of which were FILD.The positive\|rates o bFGF expressed in pulmonary macrophages of FILD cases were higher than those of disease control cases(P＜0.025).So the conclusion is that bFGF could cooperate with TGF-β₁.The two cell factors could play a part in the process of abnormal collagen deposition in FILD.     

兰州市体检人群幽门螺杆菌感染状况的调查分析

目的:调查兰州市体检人群幽门螺杆菌感染状况.方法:采用C14呼气试验检测2016年1月至12月间在兰州市第二人民医院进行体检人群幽门螺杆菌感染情况.比较在不同性别、不同年龄组间幽门螺杆菌感染率和感染强度差别.结果:3449名体检者共检出幽门螺杆菌阳性者1759人,总感染率51%,其中男性976人,感染率52.29%,女性783人,感染率48.85%,男女间感染率的差异有统计学意义(p<0.05);不同年龄组间幽门螺杆菌感染率无明显差别(p>0.05);不同性别不同年龄组间幽门螺杆菌感染率无明显差别(p>0.05);不同年龄组间幽门螺杆菌感染强度无明显差别(p>0.05);不同性别间幽门螺杆菌感染强度有显著性差异(p<0.01).结论:兰州市体检人群特别是男性体检者幽门螺杆菌感染比较严重.     

TGF-β1和bFGF在肺泡间隔胶原沉积中的作用

采用ＨＥ，Ｍａｓｓｏｎ染色和免疫组织化学方法（ＳＰ法）探讨了ＴＧＦ－β１和ｂＦＧＦ在纤维性间质性肺病胶原纤维沉积中的作用。结果表明纤维性间持性肺病晚期的肺泡间隔中，常有胶原纤维的异常沉积，肺泡间隔中胶砂纤维沉积的程度分４级，在纤维性间质性肺病组和疾病对照组之间，肺泡巨噬细胞和增生性肺泡ＩＩ型上皮细胞ＴＧＦ－β１阳性率有显著性差异（Ｐ〈０．０５）；肺泡巨噬细胞ｂＦＧＦ阳性率亦有显著性差异（Ｐ〈０．０     

子宫腺肉瘤二例临床及病理分析

子宫腺肉瘤是子宫肉瘤的罕见类型,有其特有的镜下特点和免疫组化特征。现收集2例子宫腺肉瘤病例,并结合文献探讨其诊断、鉴别诊断及临床意义,以提高对该病的认识。