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Globally,there is a great gulf between medical knowledge and clinical practice.Translating knowledge into clinical decision support(CDS) application has become the biggest challenge faced by evidence based medicine.This paper proposed a comprehensive motivation framework to facilitate knowledge translation in healthcare.Based on a unified medical knowledge ontology and knowledge base,the framework provides an infrastructure of fundamental services,such as inference service and data acquisition,to support development of knowledge-driven CDS applications and integration into clinical workflow.The framework has been implemented in a 2600-bed Chinese hospital,and is able to reduce the time and cost of developing typical CDS applications.  相似文献   
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