面向飞机PHM的大数据分析与人工智能应用

针对新一代电子产品密集型的飞机,其系统结构和失效机理复杂、失效模式多样,传统的方法难以对其进行有效健康管理的现状,因此提出了基于海量数据挖掘的飞机PHM研究。首先从系统结构、服役环境、数据来源与存储方式等角度分析了新一代飞机对海量数据挖掘的应用需求;其次论述了基于海量数据挖掘的关键技术,包括数据的预处理、集成管理、聚类、分类、关联、预测等;最后提出了一种基于私有云的飞机PHM海量数据挖掘平台,详细阐述了该平台的总体框架和软硬件结构,该平台为飞机PHM提供了验证平台,对促进飞机PHM的集成与工程化实现具有重大的军事应用意义。     

Intraluminal bile salt increases rate of firing in afferent fibers from the small intestine of the rat

Perfusion of a rat intestinal segment with a solution containing sodium deoxycholate (8 mM) increases the rate of firing in periarterial afferent nerves from the gut. This observation indirectly supports our earlier proposal that bile salt evokes a net fluid secretion in the small intestine via an activation of the enteric nervous system.     

Genome-wide association study identifies three new susceptibility loci for adult asthma in the Japanese population

Bronchial asthma is a common inflammatory disease caused by the interaction of genetic and environmental factors. Through a genome-wide association study and a replication study consisting of a total of 7,171 individuals with adult asthma (cases) and 27,912 controls in the Japanese population, we identified five loci associated with susceptibility to adult asthma. In addition to the major histocompatibility complex and TSLP-WDR36 loci previously reported, we identified three additional loci: a USP38-GAB1 locus on chromosome 4q31 (combined P = 1.87 × 10(-12)), a locus on chromosome 10p14 (P = 1.79 × 10(-15)) and a gene-rich region on chromosome 12q13 (P = 2.33 × 10(-13)). We observed the most significant association with adult asthma at rs404860 in the major histocompatiblity complex region (P = 4.07 × 10(-23)), which is close to rs2070600, a SNP previously reported for association with FEV(1)/FVC in genome-wide association studies for lung function. Our findings offer a better understanding of the genetic contribution to asthma susceptibility.     

Intraluminal bile salt increases rate of firing in afferent fibers from the small intestine of the rat

Summary Perfusion of a rat intestinal segment with a solution containing sodium deoxycholate (8 mM) increases the rate of firing in periarterial afferent nerves from the gut. This observation indirectly supports our earlier proposal that bile salt evokes a net fluid secretion in the small intestine via an activation of the enteric nervous system.This study was supported by grants from the Swedish Medical Research Council (2855), The Medical Council of Swedish Life Insurance Companies and the Faculty of Medicine, University of Göteborg.