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Harris SR Clarke IN Seth-Smith HM Solomon AW Cutcliffe LT Marsh P Skilton RJ Holland MJ Mabey D Peeling RW Lewis DA Spratt BG Unemo M Persson K Bjartling C Brunham R de Vries HJ Morré SA Speksnijder A Bébéar CM Clerc M de Barbeyrac B Parkhill J Thomson NR 《Nature genetics》2012,44(4):413-9, S1
Chlamydia trachomatis is responsible for both trachoma and sexually transmitted infections, causing substantial morbidity and economic cost globally. Despite this, our knowledge of its population and evolutionary genetics is limited. Here we present a detailed phylogeny based on whole-genome sequencing of representative strains of C. trachomatis from both trachoma and lymphogranuloma venereum (LGV) biovars from temporally and geographically diverse sources. Our analysis shows that predicting phylogenetic structure using ompA, which is traditionally used to classify Chlamydia, is misleading because extensive recombination in this region masks any true relationships present. We show that in many instances, ompA is a chimera that can be exchanged in part or as a whole both within and between biovars. We also provide evidence for exchange of, and recombination within, the cryptic plasmid, which is another key diagnostic target. We used our phylogenetic framework to show how genetic exchange has manifested itself in ocular, urogenital and LGV C. trachomatis strains, including the epidemic LGV serotype L2b. 相似文献
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