Immunohistochemical demonstration of corticotrophic cells concentrated in the rostral zone of the pars intermedia of the mouse hypophysis

Résumé La nature corticotrope des cellules constituant la partie rostrale de la pars intermedia de l'hypophyse de souris est établie par la microscopie électronique et la cytoimmunofluorescence. Cette zone réagit positivement avec les anticorps anti-ACTH et négativement avec les anticorps anti-MSH.     

Cytologie fine des cellules interstitielles du testicule du poissonLebistes reticulatus R.

Summary The active interstitial cells of the testis ofLebistes reticulatus R. have numerous, big, dense mitochondria of tubular structure and a developed endoplasmic reticulum. The formation of lipochrome pigment granules corresponds to a degenerative evolution of these cells.     

Genome-wide association analysis in primary sclerosing cholangitis identifies two non-HLA susceptibility loci

Primary sclerosing cholangitis (PSC) is a chronic bile duct disease affecting 2.4-7.5% of individuals with inflammatory bowel disease. We performed a genome-wide association analysis of 2,466,182 SNPs in 715 individuals with PSC and 2,962 controls, followed by replication in 1,025 PSC cases and 2,174 controls. We detected non-HLA associations at rs3197999 in MST1 and rs6720394 near BCL2L11 (combined P = 1.1 × 10?1? and P = 4.1 × 10??, respectively).     

Central nervous system control of food intake

New information regarding neuronal circuits that control food intake and their hormonal regulation has extended our understanding of energy homeostasis, the process whereby energy intake is matched to energy expenditure over time. The profound obesity that results in rodents (and in the rare human case as well) from mutation of key signalling molecules involved in this regulatory system highlights its importance to human health. Although each new signalling pathway discovered in the hypothalamus is a potential target for drug development in the treatment of obesity, the growing number of such signalling molecules indicates that food intake is controlled by a highly complex process. To better understand how energy homeostasis can be achieved, we describe a model that delineates the roles of individual hormonal and neuropeptide signalling pathways in the control of food intake and the means by which obesity can arise from inherited or acquired defects in their function.