Using Critical Social Heuristics and Project-Based Learning to Enhance Data Warehousing Education

The aim of this paper is to demonstrate how project-based learning can be used from a critical systems perspective in data warehousing education. Data warehousing is a discipline in information technology focusing on providing data-driven decision support systems for strategic decision making. In this study we used action research from a critical (emancipative) perspective to reflect on our current instructional design of the data warehousing module before redesigning it to better serve the needs of the involved and affected. We used critical systems heuristics and project-based learning as frameworks of understanding to guide our intervention. Project-based learning is a learning/teaching approach aimed at organising the learning experience in terms of a project. We used written interpretive interviews in the diagnosis and evaluation of success phases of our action research cycle. Our reflection is according to the action research model of Checkland reflecting on our success in the area of application (data warehousing instruction) as well as our methodology (action research from a critical social theory perspective) and our framework of ideas (project-based learning and critical social heuristics).     

The Use of Critical Systems Heuristics to Surface and Reconcile Users' Conflicting Visions for a Business Intelligence System

This paper describes an action research study where the business requirements analysis approach of a business intelligence development project was enriched. Critical systems heuristics, a critical systems methodology that is positioned in the critical systems thinking paradigm, was applied to surface the inherently conflicting views and visions (however unknown to them) that the various stakeholders had regarding a new business intelligence system and its underlying business process. It therefore enabled surfacing of human/cultural and organisational issues that would have negatively affected the adoption of the new system; these were successfully resolved. Accordingly, the various stakeholders reflected on their real requirements that constituted improvement, rather than mere automation, of a business process; it ultimately resulted in a successful new business intelligence system that realised business benefits.     

Monovalent cation leaks in human red cells caused by single amino-acid substitutions in the transport domain of the band 3 chloride-bicarbonate exchanger, AE1

We identified 11 human pedigrees with dominantly inherited hemolytic anemias in both the hereditary stomatocytosis and spherocytosis classes. Affected individuals in these families had an increase in membrane permeability to Na and K that is particularly marked at 0 degrees C. We found that disease in these pedigrees was associated with a series of single amino-acid substitutions in the intramembrane domain of the erythrocyte band 3 anion exchanger, AE1. Anion movements were reduced in the abnormal red cells. The 'leak' cation fluxes were inhibited by SITS, dipyridamole and NS1652, chemically diverse inhibitors of band 3. Expression of the mutated genes in Xenopus laevis oocytes induced abnormal Na and K fluxes in the oocytes, and the induced Cl transport was low. These data are consistent with the suggestion that the substitutions convert the protein from an anion exchanger into an unregulated cation channel.     

Interference with HIV-induced syncytium formation and viral infectivity by inhibitors of trimming glucosidase

Human immunodeficiency virus (HIV), the causative agent of AIDS, infects human lymphocytes and monocytes. An interaction between the viral envelope gp 120 and CD4 protein is required to initiate an infectious cycle. HIV infection in vitro induces syncytium formation by cell-to-cell fusion; this aspect of viral cytopathogenicity is even more dependent on gp120-CD4 interactions. That gp120 is extremely heavily glycosylated (31-36 N-linked glycans per molecule), suggests involvement of N-linked glycans in the gp120-CD4 interaction. We therefore investigated the effects of castanospermine, 1-deoxynojirimycin (dNM) and 1-deoxymannojirimycin (dMM), three trimming glycosidase inhibitors which perturb N-linked glycan structure, on induction of the formation of syncytium between HIV-infected and CD4-expressing cells. The glucosidase inhibitors castanospermine and dNM, but not the mannosidase inhibitor dMM, inhibited syncytium formation and interfered with infectivity. The potential of glucosidase inhibitors as anti-HIV therapeutic agents deserves further investigation, especially because dNM and related compounds show little toxicity in vitro and in vivo.