The epistemic value of good sense

This paper examines competing interpretations of Pierre Duhem’s theory of good sense recently defended by David Stump and Milena Ivanova and defends a hybrid reading that accommodates the intuitions of both readings. At issue between Stump and Ivanova is whether Duhemian good sense is a virtue theoretic concept. I approach the issue from the broader perspective of determining the epistemic value of good sense per se, and argue for a mitigated virtue theoretic reading that identifies an essential role for good sense in theory choice. I also show that many important issues in both philosophy of science and ‘mainstream’ value driven epistemology are illuminated by the debate over the epistemic value of good sense. In particular, philosophical work on the nature of cognitive character, rule governed rationality and the prospects of epistemic value t-monism are illuminated by virtue theoretic readings of Duhemian good sense.     

The multidrug-resistant human pathogen Clostridium difficile has a highly mobile, mosaic genome

We determined the complete genome sequence of Clostridium difficile strain 630, a virulent and multidrug-resistant strain. Our analysis indicates that a large proportion (11%) of the genome consists of mobile genetic elements, mainly in the form of conjugative transposons. These mobile elements are putatively responsible for the acquisition by C. difficile of an extensive array of genes involved in antimicrobial resistance, virulence, host interaction and the production of surface structures. The metabolic capabilities encoded in the genome show multiple adaptations for survival and growth within the gut environment. The extreme genome variability was confirmed by whole-genome microarray analysis; it may reflect the organism's niche in the gut and should provide information on the evolution of virulence in this organism.