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Genome-wide association study of quantitative resistance to southern leaf blight in the maize nested association mapping population 总被引:6,自引:0,他引:6
Kump KL Bradbury PJ Wisser RJ Buckler ES Belcher AR Oropeza-Rosas MA Zwonitzer JC Kresovich S McMullen MD Ware D Balint-Kurti PJ Holland JB 《Nature genetics》2011,43(2):163-168
Nested association mapping (NAM) offers power to resolve complex, quantitative traits to their causal loci. The maize NAM population, consisting of 5,000 recombinant inbred lines (RILs) from 25 families representing the global diversity of maize, was evaluated for resistance to southern leaf blight (SLB) disease. Joint-linkage analysis identified 32 quantitative trait loci (QTLs) with predominantly small, additive effects on SLB resistance. Genome-wide association tests of maize HapMap SNPs were conducted by imputing founder SNP genotypes onto the NAM RILs. SNPs both within and outside of QTL intervals were associated with variation for SLB resistance. Many of these SNPs were within or near sequences homologous to genes previously shown to be involved in plant disease resistance. Limited linkage disequilibrium was observed around some SNPs associated with SLB resistance, indicating that the maize NAM population enables high-resolution mapping of some genome regions. 相似文献
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