Evaluation of the hepatotoxicological effects of a drug in an in vivo/in vitro model

Both in vivo and in vitro models have certain disadvantages for the study of the chronic hepatotoxicity of drugs. The aim of this work was to evaluate a new approach based on an in vivo/in vitro model. After chronic in vivo treatment of rats with Vincamine and Vindeburnol (an eburnamenine derivative which exhibits hepatotoxic properties in man) liver cells were isolated, and functional and metabolic disorders (metabolic utilization of fructose and protein biosynthesis) were studied to determine injury. The results showed no modification of blood parameters, but a direct relationship between the dose of Vindeburnol administered in vivo and the metabolic disorders observed in vitro, evidencing the high sensitivity and reliability of this model.     

浅析市场经济条件下水资源管理的三大转变

在市场经济条件下，水资源管理要实现三大转变：一是由传统防范和利用意识向市场资源型转变，建立起水的资源观、可持续利用观和价值观；二是由行政管水的运行机制向水市场体系转变，逐步建立起市场调节与政府调控相结合的新的管理机制；三是由政出多门的管理体制向水务一体化管理体制转变，建立起“统一、高效、负责”的水务一体化管理体制。     

核能谱与两类转动惯量的精确表达式

用最小二乘拟合法,将稀土区的能谱实验数据,拟合不同的能谱公式,从而证明E=a〔(1+bI(I+1))~(1/2)-1〕是符合得较好的,本文还推导了与上述能谱相应的两类转动惯量,并以此与实验计算值进行比较,结果仍很满意.     

Evaluation of the hepatotoxicological effects of a drug in an in vivo/in vitro model.

Both in vivo and in vitro models have certain disadvantages for the study of the chronic hepatotoxicity of drugs. The aim of this work was to evaluate a new approach based on an in vivo/in vitro model. After chronic in vivo treatment of rats with Vincamine and Vindeburnol (an eburnamenine derivative which exhibits hepatotoxic properties in man) liver cells were isolated, and functional and metabolic disorders (metabolic utilization of fructose and protein biosynthesis) were studied to determine injury. The results showed no modification of blood parameters, but a direct relationship between the dose of Vindeburnol administered in vivo and the metabolic disorders observed in vitro, evidencing the high sensitivity and reliability of this model.     

Progressive impairment in high energy phosphate pattern induced by intermittent coronary perfusion

Summary After continuous myocardial ischemia, ATP and CP are both depressed. A different pattern is exhibited in the course of intermittent coronary perfusion. The drop in ATP stores is not avoided, but progressive resis in CP contents is observed.Acknowledgments. The authors are grateful to Mrs G. Boulot and Miss Bidault for excellent technical assistance.     

Magnetic characteristics and its environmental implications of core YSJD-86GC sediments from the southern South China Sea

Sediments of core YSJD-86GC （referred to as 86GC） collected from the southern South China Sea were selected for environmental magnetic studies. Combined with the published chronological framework, sediment magnetic properties were revealed for the study area since the MIS3 stage. The rock magnetic results indicate that low-coercivity magnetite is the main magnetic mineral within the sediments. Also, a certain amounts of hematite are present. The King plot and Day plot, which reflect the magnetic particle size, show that fine-grained pseudo-sin- gle-domain phase magnetic particles dominate the magnetic minerals in the sediments. Comparison of magnetic parameters and geochemical indicators show that magnetic properties of core 86GC sediments reflect a terrigenous input. Simultaneously, magnetic characteristics of the stud- ied sediment are influenced by the quantity of terrigenous sediment input, oxidation-reduction conditions of the provenance area, and the transportation environment and distance. Sea level fluctuation caused by global climate change was the main factor for variation in concentration of magnetic minerals and magnetic particle size of thestudied core sediments. Thus, variation of sediment magnetic properties in the study area can be used as an indirect indicator of sea level fluctuation.     

一种改进的规划器算法在军用软件GUI测试用例自动生成中的应用

以人工智能中智能规划方法为基础,对军用软件测试用例自动生成技术进行了研究。现有的许多规划器都不能避免组合爆炸问题的发生,而这一问题又是导致规划失败的一个重要问题,针对这一现象,以IPP规划器为例,提出目标分解法对规划器所需事实文件进行划分,并对IPP规划器应用多事实文件处理算法进行扩展,扩展后的MF-IPP规划器能够处理多个事实文档,有效避免了组合爆炸问题的发生。将该方法应用到军用主控软件GUI(Graphical User Interface)测试用例自动生成中,主要思想是首先利用规划器生成初始测试用例,其次提出解扩展的方法来完善测试用例的生成。针对测试用例生成问题进行了比对分析,结果显示,MF-IPP可以很好地防止组合爆炸问题的发生。所生成的测试用例生成时间短、覆盖率高,不仅能够很好地辅助软件测试人员进行测试用例的编写,还能应用于自动化软件测试。     

川东鄂西山地紫色土发生探讨

本文研究表明,在试验区内,地质构造决定着紫色岩层的展布和紫色土的分布;老年、壮年、青年等不同地貌发育阶段则深刻影响和制约紫色土发生演化的方向.在现代成土条件下,各地类型紫色土的发育和岩石,既存在矿质元素的相对迁移和富集.也存在元素间的彼此制约关系.实质为碱金属、碱土金属在土壤剖层次间的淋溶作用.土壤淋溶系数5.90-14.960;岩石淋溶系数2.269-4.466.