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Robert A. Fenton Hanne B. Moeller Marina Zelenina Marteinn T. Snaebjornsson Torgeir Holen Nanna MacAulay 《Cellular and molecular life sciences : CMLS》2010,67(5):829-840
Aquaporin 4 (AQP4) is expressed in the perivascular glial endfeet and is an important pathway for water during formation and
resolution of brain edema. In this study, we examined the functional properties and relative unit water permeability of three
functional isoforms of AQP4 expressed in the brain (M1, M23, Mz). The M23 isoform gave rise to square arrays when expressed
in Xenopus
laevis oocytes. The relative unit water permeability differed significantly between the isoforms in the order of M1 > Mz > M23.
None of the three isoforms were permeable to small osmolytes nor were they affected by changes in external K+ concentration. Upon protein kinase C (PKC) activation, oocytes expressing the three isoforms demonstrated rapid reduction
of water permeability, which correlated with AQP4 internalization. The M23 isoform was more sensitive to PKC regulation than
the longer isoforms and was internalized significantly faster. Our results suggest a specific role for square array formation. 相似文献
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