排序方式: 共有7条查询结果,搜索用时 109 毫秒
1
1.
2.
R Mechoulam J J Feigenbaum N Lander M Segal T U J?rbe A J Hiltunen P Consroe 《Experientia》1988,44(9):762-764
The 1,1-dimethylheptyl homolog of (-)-(3R,4R)-7-hydroxy-delta-6- tetrahydrocannabinol (compound II) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II). 相似文献
3.
R. Mechoulam J. J. Feigenbaum N. Lander M. Segal T. U. C. Järbe A. J. Hiltunen P. Consroe 《Cellular and molecular life sciences : CMLS》1988,44(9):762-764
Summary The 1,1-dimethylheptyl homolog of (–)-(3R,4R)-7-hydroxy-delta-6-tetrahydrocannabinol (compoundII) is highly psychotropic in mice, rats and pigeons. The (+)-(3S,4S) enantiomer (III) was found to be psychotropically inactive at doses up to several thousand times those of the ED50 of (II).We thank Dr A. Breuer and Mrs H. Amsalem for help with the syntheses. The research reported above was supported in Tucson by NIH grant NS 15441; in Uppsala by grants from the Swedish Medical Research Council (5757) and the Swedish Council for the Planning and Coordination of Research (84/2082); in Jerusalem by the Szold Foundation.Presented in part at a meeting at the US National Institute on Drug Abuse, Washington, D.C., October 1986, see NIDA Research Monographs79 (1987) 15. 相似文献
4.
The purpose of this study was to compare plate and conical refiner fillings in refining of softwood and hardwood pulp fibers. Contrary to expectations,better tensile strength values were achieved when BSW was refined with conical fillings and the development of strength Was found to be insensitive to variations in refining intensity. A bar microprocile was measured with the aid of a profilometer. The leading edges of conicalfilling bars.were found to be rounder. A possible reason for the better tensile strength of pulp refined with conical fillings is that the round edge helps large SW fiber flocs to enter the space between the bars, resulting in less heterogeneous or more efficient treatment of fibers.The recorded gap closure values supported the above interpretation. The gap between conical fillings was found to become wider when pulp consistency and thus fiber flocculation increased, whereas increased pulp consistency decreased the gap between plate fillings, which was further reflected as increased fiber cutting. The reduction in fiber length was proportional to the increase in gap closure,supporting the earlier theory that fibers are squeezed and crushed between the bars. More attention should be paid to the wear of filling materials when refining BSW. A filling material which wears so that the bar edges are rounded would seem to promote high tensile strength and high average fiber length. 相似文献
5.
Antonenkov VD Rokka A Sormunen RT Benz R Hiltunen JK 《Cellular and molecular life sciences : CMLS》2005,62(23):2886-2895
Mouse liver peroxisomes were isolated by centrifugation in a self-generated Percoll gradient followed by an Optiprep density
gradient centrifugation. Peroxisomes contributed 90–96% of the total protein content in the fraction, as confirmed by marker
enzyme assays, protein pattern in SDS-PAGE, immunoblotting, and electron microscopy. Solubilized peroxisomal membrane proteins
were reconstituted into a planar lipid bilayer. A single-channel conductance monitoring of the reconstituted lipid bilayer
revealed the presence of two pore-forming components with a conductance in 1 M KCl of 1.3 nS and 2.5 nS. Control experiments
with fractions enriched in mitochondria, lysosomes, and fragments of endoplasmic reticulum showed that the peroxisomal channel-forming
activities were not due to admixture of isolated peroxisomes with other cellular organelles. The peroxisomal channels were
well preserved in membrane preparations but became unstable after solubilization from the membranes by detergent.
Received 27 May 2005; received after revision 23 September 2005; accepted 11 October 2005 相似文献
6.
Cheour M Martynova O Näätänen R Erkkola R Sillanpää M Kero P Raz A Kaipio ML Hiltunen J Aaltonen O Savela J Hämäläinen H 《Nature》2002,415(6872):599-600
It is not yet clear whether humans are able to learn while they are sleeping. Here we show that full-term human newborns can be taught to discriminate between similar vowel sounds when they are fast asleep. It is possible that such sleep training soon after birth could find application in clinical or educational situations. 相似文献
7.
1