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N-terminal disulphide knot of human fibrinogen 总被引:26,自引:0,他引:26
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Yvonne G. J. van Helden Sandra G. Heil Frederik J. van Schooten Evelien Kramer Susanne Hessel Jaume Amengual Joan Ribot Katja Teerds Adrian Wyss Georg Lietz M. Luisa Bonet Johannes von Lintig Roger W. L. Godschalk Jaap Keijer 《Cellular and molecular life sciences : CMLS》2010,67(12):2039-2056
Beta-carotene 15,15′-monooxygenase 1 knockout (Bcmo1 ?/?) mice accumulate beta-carotene (BC) similarly to humans, whereas wild-type (Bcmo1 +/+) mice efficiently cleave BC. Bcmo1 ?/? mice are therefore suitable to investigate BC-induced alterations in gene expression in lung, assessed by microarray analysis. Bcmo1 ?/? mice receiving control diet had increased expression of inflammatory genes as compared to BC-supplemented Bcmo1 ?/? mice and Bcmo1 +/+ mice that received either control or BC-supplemented diets. Differential gene expression in Bcmo1 ?/? mice was confirmed by real-time quantitative PCR. Histochemical analysis indeed showed an increase in inflammatory cells in lungs of control Bcmo1 ?/? mice. Supported by metabolite and gene-expression data, we hypothesize that the increased inflammatory response is due to an altered BC metabolism, resulting in an increased vitamin A requirement in Bcmo1 ?/? mice. This suggests that effects of BC may depend on inter-individual variations in BC-metabolizing enzymes, such as the frequently occurring human polymorphisms in BCMO1. 相似文献
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Genome-wide microRNA profiling of human temporal lobe epilepsy identifies modulators of the immune response 总被引:1,自引:1,他引:0
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