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The Ror receptor tyrosine kinase family 总被引:6,自引:0,他引:6
Forrester WC 《Cellular and molecular life sciences : CMLS》2002,59(1):83-96
Receptor tyrosine kinases (RTKs) participate in numerous developmental decisions. Ror RTKs are a family of orphan receptors
that are related to muscle specific kinase (MuSK) and Trk neurotrophin receptors. MuSK assembles acetylcholine receptors at
the neuromuscular junction [1, 2], and Trk receptors function in the developing nervous system (reviewed in [3-5]). Rors have
been identified in nematodes, insects and mammals. Recent studies have begun to shed light on Ror function during development.
In most species, Rors are expressed in many tissue types during development. Analyses of mutants that are defective in the
single nematode Ror demonstrate a role in cell migration and in orienting cell polarity. Mice lacking one of the two Ror gene
products display defects in bone and heart formation. Similarly, two different human bone development disorders, dominant
brachydactyly B and recessive Robinow syndrome, result from mutations in one of the human Ror genes.
Received 17 April 2001; received after revision 2 July 2001; accepted 4 July 2001 相似文献
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A. R. Forrester 《Cellular and molecular life sciences : CMLS》1984,40(7):688-689
Summary Aqueous solutions of hermidin readily give rise to a blue transient radical-anion on exposure to air, the identity of which has been established by ESR spectroscopy.Acknowledgment. I thank Professor R. H. Thomson for helpful discussion. 相似文献
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Histones and cancer test 总被引:1,自引:0,他引:1
E W Johns J A Pritchard J L Moore W H Sutherland C A Joslin J A Forrester A J Davies A M Neville R G Fish 《Nature》1973,245(5420):98-99
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Changes in surface charge of HeLa cells during the cell cycle 总被引:1,自引:0,他引:1
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Scanning electron microscopy of healing wounds 总被引:1,自引:0,他引:1
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Electrical signals control wound healing through phosphatidylinositol-3-OH kinase-gamma and PTEN 总被引:2,自引:0,他引:2
Zhao M Song B Pu J Wada T Reid B Tai G Wang F Guo A Walczysko P Gu Y Sasaki T Suzuki A Forrester JV Bourne HR Devreotes PN McCaig CD Penninger JM 《Nature》2006,442(7101):457-460
Wound healing is essential for maintaining the integrity of multicellular organisms. In every species studied, disruption of an epithelial layer instantaneously generates endogenous electric fields, which have been proposed to be important in wound healing. The identity of signalling pathways that guide both cell migration to electric cues and electric-field-induced wound healing have not been elucidated at a genetic level. Here we show that electric fields, of a strength equal to those detected endogenously, direct cell migration during wound healing as a prime directional cue. Manipulation of endogenous wound electric fields affects wound healing in vivo. Electric stimulation triggers activation of Src and inositol-phospholipid signalling, which polarizes in the direction of cell migration. Notably, genetic disruption of phosphatidylinositol-3-OH kinase-gamma (PI(3)Kgamma) decreases electric-field-induced signalling and abolishes directed movements of healing epithelium in response to electric signals. Deletion of the tumour suppressor phosphatase and tensin homolog (PTEN) enhances signalling and electrotactic responses. These data identify genes essential for electrical-signal-induced wound healing and show that PI(3)Kgamma and PTEN control electrotaxis. 相似文献
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RNAse A mismatch cleavage analysis of 66 primary human colon tumors reveals a high incidence of K-ras genes with mutations at position 12. No apparent correlation was found between the presence of mutant oncogenes and the degree of invasiveness of the tumours but evidence for ras mutational activation in premalignant tissue was obtained. 相似文献