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Rajendran Sanalkumar Sivadasan Bindu Dhanesh Jackson James 《Cellular and molecular life sciences : CMLS》2010,67(17):2957-2968
Evolutionarily conserved Notch signaling orchestrates diverse physiological mechanisms during metazoan development and homeostasis.
Classically, ligand-activated Notch receptors transduce the signaling cascade through the interaction of DNA-bound CBF1-co-repressor
complex. However, recent reports have demonstrated execution of a CBF1-independent Notch pathway through signaling cross-talks
in various cells/tissues. Here, we have tried to congregate the reports that describe the non-canonical/CBF1-independent Notch
signaling and target gene activation in vertebrates with specific emphasis on their functional relevance. 相似文献
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Hes-1 regulates the excitatory fate of neural progenitors through modulation of <Emphasis Type="Italic">Tlx3 (HOX11L2)</Emphasis> expression 总被引:1,自引:1,他引:0
Indulekha CL Divya TS Divya MS Sanalkumar R Rasheed VA Dhanesh SB Sebin A George A James J 《Cellular and molecular life sciences : CMLS》2012,69(4):611-627
Tlx3 (HOX11L2) is regarded as one of the selector genes in excitatory versus inhibitory fate specification of neurons in distinct regions
of the nervous system. Expression of Tlx3 in a post-mitotic immature neuron favors a glutamatergic over GABAergic fate. The
factors that regulate Tlx3 have immense importance in the fate specification of glutamatergic neurons. Here, we have shown that Notch target gene, Hes-1, negatively regulates Tlx3 expression, resulting in decreased generation of glutamatergic neurons. Down-regulation of Hes-1 removed the inhibition on Tlx3 promoter, thus promoting glutamatergic differentiation. Promoter–protein interaction studies
with truncated/mutated Hes-1 protein suggested that the co-repressor recruitment mediated through WRPW domain of Hes-1 has
contributed to the repressive effect. Our results clearly demonstrate a new and unique role for canonical Notch signaling
through Hes-1, in neurotransmitter/subtype fate specification of neurons in addition to its known functional role in proliferation/maintenance
of neural progenitors. 相似文献
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