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In this paper a data analysis tool for analyzing highly correlated time series data is suggested. The main objective is to unify multiple time series into a single series and then apply a univariate method for the purpose of prediction. This method is essentially efficient for analyzing multiple time series with sparse data. Several time series data of relative demand for black and white television receivers in various countries are analyzed and quite accurate predictions are obtained. 相似文献
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Birnbaum RY Zvulunov A Hallel-Halevy D Cagnano E Finer G Ofir R Geiger D Silberstein E Feferman Y Birk OS 《Nature genetics》2006,38(7):749-751
We describe an Israeli Jewish Moroccan family presenting with autosomal dominant seborrhea-like dermatosis with psoriasiform elements, including enhanced keratinocyte proliferation, parakeratosis, follicular plugging, Pityrosporum ovale overgrowth and dermal CD4 lymphocyte infiltrate. We mapped the disease gene to a 0.5-cM region overlapping the PSORS2 locus (17q25) and identified a frameshift mutation in ZNF750, which encodes a putative C2H2 zinc finger protein. ZNF750 is normally expressed in keratinocytes but not in fibroblasts and is barely detectable in CD4 lymphocytes. 相似文献
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Hakim O Resch W Yamane A Klein I Kieffer-Kwon KR Jankovic M Oliveira T Bothmer A Voss TC Ansarah-Sobrinho C Mathe E Liang G Cobell J Nakahashi H Robbiani DF Nussenzweig A Hager GL Nussenzweig MC Casellas R 《Nature》2012,484(7392):69-74
Recurrent chromosomal translocations underlie both haematopoietic and solid tumours. Their origin has been ascribed to selection of random rearrangements, targeted DNA damage, or frequent nuclear interactions between translocation partners; however, the relative contribution of each of these elements has not been measured directly or on a large scale. Here we examine the role of nuclear architecture and frequency of DNA damage in the genesis of chromosomal translocations by measuring these parameters simultaneously in cultured mouse B lymphocytes. In the absence of recurrent DNA damage, translocations between Igh or Myc and all other genes are directly related to their contact frequency. Conversely, translocations associated with recurrent site-directed DNA damage are proportional to the rate of DNA break formation, as measured by replication protein A accumulation at the site of damage. Thus, non-targeted rearrangements reflect nuclear organization whereas DNA break formation governs the location and frequency of recurrent translocations, including those driving B-cell malignancies. 相似文献
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