Similar effects of arginine-vasopressin and arginine-vasotocin on permeability of toad skin

Résumé Des crapauds ont été employés pour doser l'action des peptides neurohypophysaires sur la perméabilité de la peau. L'arginine⁸-vasopressine et l'arginine⁸-vasotocine ont en absence de Na⁺ le même effet. Elles augmentent les mouvements de l'eau, à doses variées, et leur action à toutes deux est 2000 fois plus puissante que celle de l'oxytocine. En presence de Na⁺ l'action de l'arginine⁸-vasotocine est 3 fois plus grande que celle de l'arginine⁸-vasopressine. Elles sont respectivement 120 fois et 40 fois plus puissantes que l'oxytocine.     

Dense-cored vesicles at neuromuscular synapses of arthropods and vertebrates

Résumé Les vésicules synaptiques granulées se trouvent dans les jonctions neuromusculaires de mammifères, des crustacés, et des araignées. On ne connait pas leur fonction.

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Supported by grants from the National Research Council of Canada and the Muscular Dystrophy Association of Canada.     

Effects of estradiol on the in vitro incorporation of acetate-1-14C and choline-1,2-14C into the phospholipids of human peripheral arteries

Zusammenfassung Bei Bebrütung von Arterien in Gegenwart von Östradiol wurde der Einbau von¹⁴C-Azetat und¹⁴C-Cholin in Phosphatidylcholin deutlich vermehrt.     

New scanning electron microscopy contribution to the study of yeast protoplasts]

Study by scanning electron microscopy enables us to describe with precision the morphology of protoplasts. We can confirm that the wrinkles more or less perceptible on the protoplasts studied, do belong to the morphology of those just mentioned, that the presence or the absence of globulous component is connected with the physiological activity of the cell and that it is possible to distinguish the different protoplasts thanks to their morphological aspect.     

Visceral localization of 14C gentamicin in the rat after administration of a single dose

When administered intravenously to Rats, 14C Gentamicin decreased very fast in all tissues, except in kidney and cartilage. Some flexures of the small intestine contained radioactive carbon, and that was evidence for the biliary elimination of a part of the aminoglycoside. In animals with water restriction, the distribution of the antibiotic in tissues was similar to the distribution in animals with free access to water.     

Heritable germline epimutation of MSH2 in a family with hereditary nonpolyposis colorectal cancer

Epimutations in the germline, such as methylation of the MLH1 gene, may contribute to hereditary cancer syndrome in human, but their transmission to offspring has never been documented. Here we report a family with inheritance, in three successive generations, of germline allele-specific and mosaic hypermethylation of the MSH2 gene, without evidence of DNA mismatch repair gene mutation. Three siblings carrying the germline methylation developed early-onset colorectal or endometrial cancers, all with microsatellite instability and MSH2 protein loss. Clonal bisulfite sequencing and pyrosequencing showed different methylation levels in different somatic tissues, with the highest level recorded in rectal mucosa and colon cancer tissue, and the lowest in blood leukocytes. This mosaic state of germline methylation with different tissue distribution could act as the first hit and provide a mechanism for genetic disease inheritance that may deviate from the mendelian pattern and be overlooked in conventional leukocyte-based genetic diagnosis strategy.