The effects of IPC,CIPC, sevin and zectran onBacillus subtilis

Résumé On a étudié les effets phénotypiques et génotypiques de 2 insecticides (Sevin et Zectran) et 2 herbicides (IPC et CIPC) surB. subtilis. Les composés carbamiques inhibent la croissance, induisent une tendance à la formation de longues chaînes. Ils n'ont toutefois pas un effet mutagénique sur le locus de l'indole deB. subtilis.This work was supported by Research Contract No. PH 43-64-57 National Cancer Institute, National Institutes of Health, Public Health Service and is paper No. 40 published under this contract.     

Ethical Issues and Role Duality in Insider Action Research: Challenges for Action Research Degree Programmes

Insider action research describes the process when a member of an organisation undertakes an explicit action research role in addition to the normal functional roles they hold in an organisation. Real-world work-based research is relevant and important to many full-time managers, consultants and members of organisations including those who choose to undertake higher degrees in business as part-time postgraduate students. Within these programmes a proposal for an insider action research project is often associated with important and interesting research projects that have already arisen in an organisation where the researcher works full-time, and are part of their existing role and established working relationships with key stakeholders. Ethical issues in organisationally located insider action research can differ from other forms of action research because of role duality, i.e. that the researcher holds an ongoing work role and power relationships associated with this as well as the action research role. Ethical issues can be associated with choices about alternative options, expected impacts and outcomes on the researcher, participants, organisation and stakeholders, and these are important considerations for academic supervisors, institutional review boards and human research ethics committees.     

Genome-wide association analyses identify 13 new susceptibility loci for generalized vitiligo

We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 × 10(-8)), MC1R (P = 1.82 × 10(-13)), a region near TYR (P = 1.57 × 10(-13)), IFIH1 (P = 4.91 × 10(-15)), CD80 (P = 3.78 × 10(-10)), CLNK (P = 1.56 × 10(-8)), BACH2 (P = 2.53 × 10(-8)), SLA (P = 1.58 × 10(-8)), CASP7 (P = 3.56 × 10(-8)), CD44 (P = 1.78 × 10(-9)), IKZF4 (P = 2.75 × 10(-14)), SH2B3 (P = 3.54 × 10(-18)) and TOB2 (P = 6.81 × 10(-10)). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration.