排序方式: 共有1条查询结果,搜索用时 0 毫秒
1
1.
Vesicle budding and fusion underlies many essential biochemical deliveries in eukaryotic cells, and its core fusion machinery
is thought to be built on one protein family named soluble N-ethylmaleimide-sensitive factor attachment protein receptor (SNARE).
Recent technical advances based on site-directed fluorescence labelling and nano-scale detection down to the single-molecule
level rapidly unveiled the protein and the lipid intermediates along the fusion pathway as well as the molecular actions of
fusion effectors. Here we summarize these new exciting findings in context with a new mechanistic model that reconciles two
existing fusion models: the proteinaceous pore model and the hemifusion model. Further, we attempt to locate the points of
action for the fusion effectors along the fusion pathway and to delineate the energetic interplay between the SNARE complexes
and the fusion effectors.
Received 01 July 2008; received after revision 29 August 2008; accepted 23 September 2008 相似文献
1