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1.
为研究肿瘤坏死因子相关凋亡诱导配体(TRAIL)与组织激肽释放酶结合蛋白(kallistatin)联合用药的抗肿瘤作用,构建TRAIL与kallistatin双表达的重组质粒pAM-CAG-Kal-IRES-TRAIL,将重组质粒转染A549,LO-2,NCI-H446和Hela细胞,考察其抗肿瘤活性.实验结果表明:构建的双表达载体能同时表达TRAIL与kallistatin,且均能分泌至培养基中;TRAIL与kallistatin联合表达对肿瘤细胞活力的抑制作用明显增强,诱导肿瘤凋亡的作用也明显增强,说明联合表达TRAIL与kallistatin能够增强抗肿瘤活性. 相似文献
2.
为研究飞秒光源作为链路初始光源的可行性,使用阵列波导光栅(AWG)对265 fs光纤光源进行波分解复用 复用实验。实验光源波长为1 52765~1 56505 nm,通道数为48,通道间隔为080 nm。研究发现:在分波实验中,飞秒光纤光源经过AWG后,扫描谱线3 dB带宽为064 nm ,相邻通道串扰为2726 dB,比连续光源增大502 dB;在合波实验中,观察到AWG多端口端对宽带光源的波长选择作用,验证了AWG的色散特性,发现多光束的输出谱线总体轮廓未出现太大变形;在波分解复用 复用实验中,谱线最大损耗为251 dB,输出谱线轮廓和初始光谱基本一致,信号在传输过程中未出现明显失真,证明飞秒光源作为链路初始光源的可行性。 相似文献
3.
以气管滴注方法研究了ApoE-/一小鼠经PM2.5暴露后,其主动脉弓中SUMO-1, HIF- la、血管内皮生长因子(VEGF)表达变化规律及HIF- la的SUMO化修饰情况.实验结果显示:PM2.5暴露后,小鼠主动脉SUMO-1,HIF-la,VEGF的表达上调;PM2.5暴露诱导了SUMO-1对HIF- la的SUMO化修饰;低氧条件下SUMO-1敲低导致HIF-la表达的下调结果提示PM2.5暴露通过上调细胞中SUMO-1的表达,稳定或者上调HIF- la的表达,进而影响血管内皮生长因子(VEGF)的表达,造成动脉粥样硬化斑块的不稳定. 相似文献
4.
为了快速处理航天情报,基于数据驱动的深度学习技术,提出融合多源异构知识标注中文航天情报数据集的方法流程,以及基于预训练(pre-training)模型的航天情报实体识别(AIER)方法;通过对航天情报进行命名实体识别,达到对航天情报进行信息抽取的目的.通过融合BERT(bidirectional encoder representation from transformers)预训练模型和条件随机场(CRF)模型构建AIER模型(BERT-CRF模型),将其与隐马尔可夫模型(HMM)、条件随机场(CRF)模型、双向长短期记忆网络加条件随机场(BiLSTM-CRF)模型进行实体识别对比实验.结果表明:基于预训练模型的AIER模型能够取得93.68%的准确率、97.56%的召回率和95.58%的F1值;相比于其他方法,基于预训练模型方法的性能得到提高. 相似文献
5.
借助光纤布拉格光栅(FBG)传感器,在不同浸润时间下,对碳纤维复合材料(CFRP)锚固结构进行周期荷载实验,探究水浸与周期荷载下CFRP锚固结构的耐久性.试验结果表明:随着循环次数的增加,环氧体塑性变形减小,并趋于稳定;水浸与周期荷载作用下,锚具内CFRP筋发生变形,但无脱锚现象发生;CFRP筋与环氧体界面受水浸环境影响小,筋材表面无腐蚀. 相似文献
6.
LIU Yu * CAI QiuFang SONG HuiMing AN ZhiSheng & Hans W. LINDERHOLM The State Key Laboratory of Loess Quaternary Geology Institute of Earth Environment Chinese Academy of Sciences Xi’an China Department of Environmental Science Technology School of Human Settlements Civil Engineering Xi’an Jiaotong University Xi’an Graduate University of Chinese Academy of Sciences Beijing Regional Climate Group Department of Earth Sciences... 《科学通报(英文版)》2011,(Z2):2986-2994
Amplitudes, rates, periodicities, causes and future trends of temperature variations based on tree rings for the past 2485 years on the central-eastern Tibetan Plateau were analyzed. The results showed that extreme climatic events on the Plateau, such as the Medieval Warm Period, Little Ice Age and 20th Century Warming appeared synchronously with those in other places worldwide. The largest amplitude and rate of temperature change occurred during the Eastern Jin Event (343-425 AD), and not in the late 20th century. There were significant cycles of 1324 a, 800 a, 199 a, 110 a and 2-3 a in the 2485-year temperature series. The 1324 a, 800 a, 199 a and 110 a cycles are associated with solar activity, which greatly affects the Earth surface temperature. The long-term trends (>1000 a) of temperature were controlled by the millennium-scale cycle, and amplitudes were dominated by multi-century cycles. Moreover, cold intervals corresponded to sunspot minimums. The prediction indicated that the temperature will decrease in the future until to 2068 AD and then increase again. 相似文献
7.
Waveform diversity based sonar system for target localization 总被引:2,自引:1,他引:1
Lijie Zhang Jianguo Huang Yong Jin Yunshan Hou Min Jiang Qunfei Zhang .College of Marine Northwestern Polytechnical University Xi’an P.R.China .Yichang Testing Technique Research Institute Yichang 《系统工程与电子技术(英文版)》2010,21(2):186-190
A new monostatic army system taking advantage of diverse waveforms to improve the performance of underwater target localization is proposed.Unlike the coherent signals between different elements in common active array,the transmitted signals from different elements here are spatially orthogonal waveforms which allow for array processing in the transit mode and result in an extension of array aperture.The mathematical derivation of Capon estimator for this sonar system is described in detail.And the performance of this orthogonal-waveform based sonar is analyzed and compared with that of its phased-array counterpart by water tank experiments.Experimental results show that this sonar system could achieve 12 dB-15 dB additional array gain over its phased-array counterpart,which means a doubling of maximum detection range.Moreover,the angular resolution is significantly improved at lower SNR. 相似文献
8.
LI YingTao LONG ShiBing LIU Qi Lü HangBing LIU Su & LIU Ming * School of Physical Science Technology Lanzhou University Lanzhou China Laboratory of Nano-Fabrication Novel Device Integration Institute of Microelectronics Chinese Academy of Sciences Beijing 《科学通报(英文版)》2011,(Z2):3072-3078
With recent progress in material science, resistive random access memory (RRAM) devices have attracted interest for nonvolatile, low-power, nondestructive readout, and high-density memories. Relevant performance parameters of RRAM devices include operating voltage, operation speed, resistance ratio, endurance, retention time, device yield, and multilevel storage. Numerous resistive-switching mechanisms, such as conductive filament, space-charge-limited conduction, trap charging and discharging, Schottky Emission, and Pool-Frenkel emission, have been proposed to explain the resistive switching of RRAM devices. In addition to a discussion of these mechanisms, the effects of electrode materials, doped oxide materials, and different configuration devices on the resistive-switching characteristics in nonvolatile memory applications, are reviewed. Finally, suggestions for future research, as well as the challenges awaiting RRAM devices, are given. 相似文献
9.
LI Feng LI Ying JIANG Wei WANG ZhenFang & LI JiLun State Key Laboratory for Agro-biotechnology Department of Microbiology China Agricultural University Beijing China School of Life Science Anhui Key Laboratory of Plant Resources Biology Huaibei Coal Industry Teachers’ College Huaibei 《科学通报(英文版)》2009,(9)
A magnetosome-deleted mutant NM21 of Magnetospirillum gryphiswaldense MSR-1 was generated by mini-Tn5 lacZ2 transposon mutagenesis, and a 3073-bp fragment flanking mini-Tn5 lacZ2 in NM21 was cloned by Anchored PCR. Sequencing analysis showed that this fragment involved three putative ORFs; the mini-Tn5 lacZ2 was inserted into ORF1. Functional complementary test indicated that the 3073-bp fragment was required for biosynthesis of magnetosomes in M. gryphiswaldense MSR-1. The majority of proteins, which had h... 相似文献
10.
Radon-Nikodym theorem in signed Loeb space 总被引:1,自引:0,他引:1
MA Chunhui LI Shenggang SHI Yanwei . College of Mathematics Information Science Shaanxi Normal University Xi’an Shaanxi China . School of Science Xi’an Architecture Technology University Xi’an . Department of Basic Courses Xi’an Peihua University Xi’an 《武汉大学学报:自然科学英文版》2010,15(1):21-24
This paper gives the Radon-Nikodym theorem in signed Loeb space under 1-saturated nonstandard model. First,the nonstandard characterization of absolute continuity is discussed,on which Radon-Nikodym theorem in signed Loeb space is obtained. Then,some facts about a finite signed Loeb measure and its variation are shown. 相似文献