斜拉网壳结构的非线性地震响应特性

斜拉网壳结构是新型结构类型,可实现用较小构件截面尺寸跨越更大空间的要求。据此推导了空间杆单元几何非线性刚度矩阵,简述了斜拉索非线性问题,给出了地震作用下斜拉网壳结构非线性地震响应计算策略;数值分析了该类结构非线性地震响应问题,并与网壳结构计算结果进行对比。     

肝片吸虫DNA疫苗的构建及其免疫效应的初步研究

用ＥcorRI酶切含肝片吸虫保护性抗原基因ＦＨ３的重组质粒pUC18/FH3,回收ＦＨ３（－１．０Ｋb)片段克隆到真核表达载体pBlueCMV上,酶切筛选顺向插入重组子pBlueCMV-FH3,即得到一种肝片吸虫ＤＮＡ疫苗,制备纯化该疫苗并免疫小鼠,小鼠肌肉细胞中有一定的ＦＨ３抗原表达;用ＥＬＩＳＡ检测抗血清表明,注射疫苗的小鼠均伴随产生一定量的特异性抗体,用肝片吸早囊蚴攻击（２０囊蚴／鼠）小鼠,初步显示有一定的减虫率。     

脂氧合酶--植物抗胁迫响应的关键酶

在植物抗胁迫响应中。脂氧合酶途径在抗性机制中非常重要．脂氧合酶是一种非血红素铁蛋白,在生物体内的主要作用是催化含有顺,顺-1,4-戊二烯结构的多不饱和脂肪酸加合氧分子,生成具有共轭双键的多不饱和脂肪酸的过氧化物及其一系列次生产物,如C3-,C6-,C9-和C12-醛、酮、醇、酸、酯等低分子量易挥发产物。它们和茉莉酸（茉莉酸甲酯）等构成植物抗性系统的信号分子诱导抗性蛋白合成及一系列抗胁迫反应．本文详述了脂氧合酶的结构、特性、作用机理、生理作用、活性测定方法和人工模拟。     

拱型波纹钢屋盖结构风振响应的频域分析

拱型波纹钢屋盖结构自重轻,在风荷载作用下结构的动力响应较为显著,在设计中应给予足够重视.利用ANSYS有限元软件中的壳单元Shell63模拟拱型波纹钢屋盖结构,研究了结构的自振频率和振型,并对结构在脉动风荷载作用下的性能进行了随机振动分析.研究成果不仅验证了脉动风荷载对这种结构是一种非常不利的荷载形式,而且给出了这种结构风振系数的建议取值.     

中美两国应对气候变化政策与公众气候素养之比较研究

极端天气给人类的生产生活和经济发展带来了极为严重的影响,气候变化成为国际社会共同关注的问题。科学研究认为温室气体排放是造成气候变暖的主要原因。中美两国作为温室气体排放大国,减排国策对本国及国际社会都具有重要影响。而公众作为应对气候变化政策的参与者,一方面他们的认知会受到政府出台政策的影响,另一方面他们对气候变化问题的认知程度也会直接影响着政策的执行效果。通过比较中美两国应对气候变化政策的异同,分析两国民众对气候变化问题的认知状况,可以为制定气候变化政策提供更为合理的建议。     

CD8<Superscript>+</Superscript> T cell response mediates the therapeutic effects of oncolytic adenovirus in an immunocompetent mouse model

The role of anti-tumor immune responses in oncolytic adenoviral therapy has not been well studied due to lack of efficacious tu- mor model in immunocompetent mice.Here,we evaluated the contributions of immune components to the therapeutic effects of oncolytic adenoviruse in an immunocompetent murine tumor model permissive for infection and replication of adenovirus.We found that CD8+T cells were critical mediator for antitumor efficacy by oncolytic adenovirus.Intratumoral viral therapy induced intensive infiltration of CD8+T cells in tumor,increased tumor-specific IFN-?(interferon-?)production and CTL(cytotoxic T lymphocyte)activity of lymphocytes,and generated a long-term tumor-specific immune memory.Boosting CD8+T cell responses by agonistic anti-4-1BB(cluster differentiation 137,CD137)antibody showed synergistic anticancer effects with oncolytic viro- therapy.Our results provide insight into antitumor mechanisms of oncolytic adenovirus in addition to their direct oncolytic effect.     

基于屈服强度与支座分布影响的LRB隔震效果研究

以一座典型的三跨连续梁桥为工程背景,采用Bouc-Wen恢复力模型模拟铅芯橡胶支座(LRB)的力-位移非线性滞回特性,建立了LRB隔震与非隔震连续梁桥有限元模型,编制了运用Runge-Kutta迭代法和Newmark时间积分法联合求解全桥非线性运动方程的时程分析程序。利用程序并结合算例对影响隔震效果的LRB屈服强度与墩、台处LRB的分布等因素进行了分析。分析结果表明:增大LRB的屈服强度,可以显著抑制梁体的位移,但会导致LRB在其它关键部位隔震效果的下降;在桥墩处多布置LRB,会提高桥台剪力隔震率,但会导致LRB在除桥台剪力外的其它关键部位隔震效果的下降。     

单桩纵向非线性响应的简化分析模型

在Winkler地基梁模型的基础上,提出了一个新的、研究单桩纵向非线性响应的一维简化分析模型.其中,采用随深度均匀分布的纵向非线性弹簧,模拟地基土对桩轴的纵向非线性作用力,非线性弹簧恢复力采用描述迟滞非线性材料本构关系的Bouc-Wen模型.计算结果表明,该简化模型可以较好地模拟各种单桩纵向非线性响应问题,反映了单桩纵向非线性行为的主要特征,能够揭示材料非线性因素对单桩轴向响应的影响.     

压裂裂缝网络不稳态流动半解析模型

与压裂单条缝及多条缝的流动模式不同,包含相互交错裂缝的压裂裂缝网络流动会在裂缝交汇处产生流向重定向和流量重分配的过程。通过引入星三角变换法,并结合有限差分方法对这一特殊流动过程进行描述,推导裂缝网络内部流动数值解。基于Laplace空间源函数及叠加原理建立油藏流动解析解。耦合该两部分流动,给出一个压裂裂缝网络不稳态流动半解析模型,并利用现场实例验证模型的实用性。结果表明:该模型可以处理裂缝空间位置和导流能力任意分布的裂缝网络,能够预测生产井的压力、产量动态及不同生产阶段的油藏压力分布;在上下封闭无界储层中,压裂缝网存在裂缝内部线性流、裂缝与地层双线性流、地层线性流、过渡流以及拟径向流;受井筒存储效应的影响,观测不到裂缝内部线性流;渗透率为1×10-7μm2级别的储层在生产早、中期流体流动主要集中在密度大及导流能力高的裂缝附近,但最终(生产30~50 a)的泄流区域都局限在压裂改造范围内,改造区外的储层流体很少流动。     

Cloud microphysical and rainfall responses to zonal perturbations of sea surface temperature: A cloud-resolving modeling study

The cloud microphysical and rainfall responses to zonal perturbations of sea surface temperature (SST) are investigated by analyzing the equilibrium simulation data (from day 31–40) obtained from a series of two-dimensional cloud-resolving simulations with a zonal model domain of 768 km. Four experiments imposed by zonal SST perturbations of wavenumbers 1 (SST29Z1), 2 (SST29Z2), 4 (SST29Z4), and 8 (SST29Z8) are compared to the control experiment imposed by zonally uniform SST (SST29). The model domain mean SST is 29 C, and the two-dimensional cloud-resolving model with a cyclic lateral boundary is also imposed by zero vertical velocity and constant zonal wind. The time and model domain mean surface rain rates in SST29Z1, SST29Z2, and SST29Z8 are about 10% larger than those in SST29, whereas the mean surface rain rates in SST29Z4 and SST29 are similar. The analysis of mean surface rainfall budgets shows that local water vapor and hydrometeor changes play important roles in determining the differences and similarities in mean surface rain rate between the perturbation experiments and the control experiment. Both convective and stratiform rain rates are larger in SST29Z1 and SST29Z2 than in SST29 due to the smaller advection of rain from convective regions into raining stratiform regions and the larger vapor condensation rates associated with the larger water vapor convergence over raining stratiform regions in SST29Z1 and SST29Z2. The convective rain rates are larger in SST29Z4 and SST29Z8 than in SST29 because of the larger condensation rates associated with the larger water vapor convergence over convective regions in SST29Z4 and SST29Z8. The stratiform rain rates in SST29Z4 and SST29Z8 are smaller than in SST29 due to the smaller vapor condensation rates and smaller collection rates of cloud water by rain over raining stratiform regions in SST29Z4 and SST29Z8.