基于联想记忆模型的炮兵战场目标价值分析

目标价值分析是炮兵作战情报信息处理的中心工作。如何从炮兵战场众多目标情报中确定其价值 ,并根据作战需要选择需射击的目标和确定优先顺序是炮兵指挥员及其参谋人员的一项重要任务。根据联想记忆的一般模型和迭代解法对炮兵战场目标价值进行了分析和排序 ,并运用计算机进行处理 ,为炮兵指挥员的决策行为提供了依据。     

体育专业体操"目标-主体-发展"教学模式的实验研究

针对体育专业体操教学的现状及教学模式存在的问题，在体操教学中进行“目标—主体—发展”教学模式的实验研究，通过对辽宁师范大学体育学院2000级两班进行的教学实验，研究“目标—主体—发展”教学模式的活动流程、教学特点和理论依据。     

感染病毒机器的控制和处理方法探析

由于病毒给网络的正常运行带来很大的危害,中毒机器应该及时处理.在主要利用域名系统和防火墙的功能的基础上,研究和设计出一种引导用户自己解决病毒问题的思路和方法,一定程度上减轻了网管人员的工作量,从而更加有效地管理校园网.     

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

The fraction of pyruvate dehydrogenase complex (PDC) in the active form is reduced by the activities of dedicated PD kinase isozymes (PDK1, PDK2, PDK3 and PDK4). Via binding to the inner lipoyl domain (L2) of the dihydrolipoyl acetyltransferase (E2 60mer), PDK rapidly access their E2-bound PD substrate. The E2-enhanced activity of the widely distributed PDK2 is limited by dissociation of ADP from its C-terminal catalytic domain, and this is further slowed by pyruvate binding to the N-terminal regulatory (R) domain. Via the reverse of the PDC reaction, NADH and acetyl-CoA reductively acetylate lipoyl group of L2, which binds to the R domain and stimulates PDK2 activity by speeding up ADP dissociation. Activation of PDC by synthetic PDK inhibitors binding at the pyruvate or lipoyl binding sites decreased damage during heart ischemia and lowered blood glucose in insulin-resistant animals. PDC activation also triggers apoptosis in cancer cells that selectively convert glucose to lactate. Received 25 August 2006; received after revision 20 November 2006; accepted 20 December 2006     

Starch-binding domains in the post-genome era

Starch belongs to the most abundant biopolymers on Earth. As a source of energy, starch is degraded by a large number of various amylolytic enzymes. However, only about 10% of them are capable of binding and degrading raw starch. These enzymes usually possess a distinct sequence-structural module, the so-called starchbinding domain (SBD). In general, all carbohydrate-binding modules (CBMs) have been classified into the CBM families. In this sequence-based classification the individual types of SBDs have been placed into seven CBM families: CBM20, CBM21, CBM25, CBM26, CBM34, CBM41 and CBM45. The family CBM20, known also as a classical C-terminal SBD of microbial amylases, is the most thoroughly studied. The three-dimensional structures have already been determined by X-ray crystallography or nuclear magnetic resonance for SBDs from five CBM families (20, 25, 26, 34 and 41), and the structure of the CBM21 has been modelled. Despite differences among the amino acid sequences, the fold of a distorted β-barrel seems to be conserved together with a similar way of substrate binding (mainly stacking interactions between aromatic residues and glucose rings). SBDs have recently been discovered in many non-amylolytic proteins. These may, for example, have regulatory functions in starch metabolism in plants or glycogen metabolism in mammals. SBDs have also found practical uses. Received 25 May 2006; received after revision 26 June 2006; accepted 3 August 2006     

受托责任论与决策有用论的影响——我国会计目标的现实选择

会计目标关系到会计基本理论框架的构建以及会计实务的拓展。美国会计界关于会计目标的研究形成两个主要流派——受托责任学派和决策有用学派。探讨了这两种观点对会计理论和实务的影响,以构建出真正符合我国现阶段经济环境的会计目标理论。     

高职高专《会计信息系统》课程教学改革的探讨

针对高职高专《会计信息系统》课程教学的现状,探讨了《会计信息系统》课程教学改革的主要内容。     

因子分析-导数光谱法测定苯酚和间苯二酚混合物

本文测定了苯酚和间苯二酚混合体系的一阶导数光谱数据,用目标因子分析对这些导数数据进行处理,以探索因子分析在导数光谱中应用的可能性。在不加任何分离的情况下,成功地确定了苯酚和间苯二酚混合体系中的物种数、物种种类及含量。     

中国管理会计发展及对策

介绍了管理会计在我国的发展状况,阐述了未来我国发展管理会计时应注意的一些问题,探讨了我国管理会计的发展方向,并针对我国管理会计存在的问题提出了相应的对策.     

基于PiggyBac转座系统的低溢漏诱导型Tet-On过表达体系的建立及应用

为避免诱导基因稳定表达的Tet-On诱导表达系统溢漏表达,实现简便且高效的外源基因稳定诱导表达, 本研究拟在Tet-On调控的转录水平基础上,将基于稳定配体Shield-1的不稳定结构域FK506结合蛋白引入目的基因的N端,从蛋白水平控制其本底表达水平.为验证该系统的效果,本研究以荧光蛋白TdTomato为报告基因,经流式分析结果证明优化后的体系较原体系的溢漏表达在蛋白水平上降低7倍左右.将该系统应用于基于小鼠胚胎干细胞的体外牙向分化模型,在诱导因子Dox和稳定配体Shield-1的协同作用下,诱导表达牙齿发育相关转录因子Hand2提高了牙向分化诱导的完成度.