Discrete Element Simulation of Collision-Rich Dynamics of Wet Granular Flows Down an Inclined Channel

This paper proposes a numerical scheme that employs the discrete element method (DEM) to simulate the motion of a wet granular flow down an inclined channel. To account for the liquid influences on the dynamics between paired particles, this paper presents a wet soft-sphere contact model with liquid-modified parameters. The developed scheme takes full advantage of DEM and avoids the expensive simulation of the solid-liquid interactions with conventional Navier-Stokes equation solver. This wet contact model has been implemented in an in-housed parallel discrete objects simulation system - KNIGHT and ANNE/IRIS to compute the dynamic behaviors of both dry and wet granular particles flowing down an inclined channel.     

Dietary vitamin E does not protect from endotoxin-induced hepatic microvascular dysfunction

Starting from the concept that lipopolysaccharide (LPS)-associated hepatotoxicity involves the action of reactive oxygen species, the present study was conducted to test whether vitamin E, a lipophilic antioxidant, prevents LPS-induced hepatic microvascular dysfunction and liver injury. Fifty-two rats were divided into three groups and fed diets containing 0 (n=16), 75 (n=18) or 8000 mg (n=18) α-tocopherol acetate/kg food for four weeks. At 1 h and 6 h after intravenous LPS-exposure (10 mg/kg E. coli LPS) hepatic microvascular response and liver injury were assessed by the analysis of Kupffer cell phagocytic activity, leukocyte-endothelial cell interaction and nutritive sinusoidal perfusion (intravital fluorescence epi- illumination technique) as well as bile flow, serum liver enzyme activities and tissue histomorphology. In animals fed with 75 mg vitamin E/kg (standard diet), LPS caused hepatic Kupffer cell activation (increased phagocytic activity) and hepatic microvascular leukocyte activation, with stasis in sinusoids and adherence in postsinusoidal venules (1 h) followed by leukocytic infiltration into tissue (6 h) and progredient sinusoidal perfusion failure (6 h). Hepatic microvascular injury was accompanied by reduced bile flow and enhanced liver enzyme release. Vitamin E-enriched diet (8000 mg/kg) and even vitamin E-deficient diet did not significantly affect LPS-induced hepatic microvascular cell activation and perfusion failure. Thus, we conclude, that vitamin E is not effective to protect from endotoxin-induced hepatic microvascular dysfunction. Received 7 November 1996; received after revision 30 December 1996; accepted 20 January 1997     

稀土或过渡金属离子晶场光谱热移位的解析研究

按照稀土或过渡金属离子晶场光谱的理论，热移位包括不同特征的４项贡献，在本文中，我们用解析方法详细讨论了这４项贡献中最重要的单声子项听积分主值问题。     

极化子自陷能的温度依赖性

本文讨论了界面磁极化了自陷能的温度依赖性。     

CH_3(CH_2)_nX的气相标准生成焓与结构因子n·(1±1/(4n))~2的线性关系

本文研究了影响 CH_3-(-CH_2-)_nX(x=-H、-OH、-SH、-Cl、-Br)的气相标准生成焓的各种因素.提出了一个计算通式:Δ_fH_m~8[CH_3(?)CH_2(?)_nX,g]=A+B·n(1±1/(4n))~2.通过50个化合物的计算,与实验值完全吻合,并预示了60个化合物的气相标准生成焓.     

H—原子组态相互作用中的核运动效应

本文论述了原子组态相互作用中的核运动效应,采用CI(Configuration-Interantion)方法计算H~-原子在这种核运动效应中产生的能量修正值,得出较为精确的结果。本文还分析了这种核运动效应的物理机制,探讨了检测的可能途径。     

Boron-based Drug Design for Cancer Therapy

1 Results Selective inhibition of protein tyrosine kinases is gaining importance as an effective therapeutic approach for the treatment of a wide range of human cancers.The epidermal growth factor receptor (EGFR) protein tyrosine kinase is one of the important kinases that play a fundamental role in cell growth signal pathways.We focused on the 4-anilinoquinazoline framework,which is observed in both compounds as a common structure.A boron atom has a vacant orbital and interconverts with ease between th...     

机器人-多人交流中交流对象的选择机制——一种基于交流意愿度的方法

在机器人越来越多地进入家庭使用的背景下,其与人类进行交流的能力日益重要,如何选择合适的交流对象,成为机器人技术面临的一个重要问题.关于这方面的研究很多,主要是处理机器人-人这种一对一的交流方式的研究,对于机器人-人群交流中合适交流对象的选择机制研究很少.根据对人类交流对象的选择标准的研究,提出了交流意愿度的概念,并在此基础上给出了选择交流对象的方法.     

液相色谱法研究有机溶质与醋酸纤维素膜表面的相互作用

用醋酸纤维素(CA)反渗透膜作为液相色谱固定相,溶剂水作为流动相,模拟反渗透分离过程中表面的平衡效应,测出了一些不同有机溶质在醋酸纤维素(CA)膜表面与水溶液间的平衡分配系数k。结果表明,大多数酸性小于水的有机溶质(醇、醛、酮)的k值小于水的k值。证明这些溶质在CA膜表面是负吸附,与优先吸附-毛细孔流理论的推断一致,与Sourirajan的色谱实验结果不同。讨论了不同类型有机溶质与CA表面的相互作用特性,较好地解释了CA膜对这些溶质的分离效果,初步探讨了溶质与膜表面的相互作用与反渗透分离率之间的关系。