大学生完美主义研究

利用分层随机抽取的257名大学生完美主义量表为资料，运用多元统计分析中因子分析方法，对大学生完美主义人格特质及其与心理健康的关系进行了定量分析和评价。结果表明：大学生在完美主义量表所有维度上的得分上不存在显著的年级差异；在担心出错、父母期望、对行动的疑虑、组织性4个维度上的得分不存在显著的性别差异，但在个人标准维度上男生的得分显著高于女生。在完美主义的维度中，担心出错与心理健康总分及各个因子分均存在显著的正相关，对行动的疑虑与心理健康总分及大部分因子分存在显著的正相关。担心出错和对行动的疑虑对大学生心理健康产生显著影响．是大学生心理健康的影响变量。     

香荚兰化学成分及栽培技术研究进展

香荚兰属(Vanilla)为兰科(Orchidaceae)攀缘植物,其果实制品香荚兰豆是目前食品工业和香料产品的重要原料,具有较高的经济价值,享有“香料之王”的美称。香荚兰豆的化学成分主要为香兰素、香兰醇、香兰酸以及脂肪族类、糖苷类、有机酸类化合物,具有抗氧化、抑菌、抗肿瘤等药理作用。香荚兰广泛应用于香料、观赏园艺,并可用于治疗癫痫、肿瘤等。本文对香荚兰的化学成分与药理作用、应用专利和栽培技术等方面进行综述,以期为香荚兰的进一步研究和开发利用提供参考。     

光学教学改革的探索与实践

光学教学改革的基本做法是在教学中不断介绍新的应用技术 ,保持教学内容与方法的先进性 ;并在教学中适时引进实验演示 ,突出对物理过程的分析 ,提高学生的科学能力 ,收到了好的教学效果。     

几种氟哌酸衍生物的抑菌作用

通过对氟哌酸结构改进，获得了１３种氟哌酸衍生物，经药理实验对大肠杆菌、枯草杆菌、变形杆菌均有不同程度的抑菌作用，为开发新药做了初步探讨。     

A pathway profile-based method for drug repositioning

Finding new applications for existing pharmaceuticals,known as drug repositioning,is a validated strategy for resolving the problem of high expenditure but low productivity in drug discovery.Currently,the prevalent computational methods for drug repositioning are focused mainly on the similarity or relevance between known drugs based on their "features",including chemical structure,side effects,gene expression profile,and/or chemical-protein interactome.However,such drug-oriented methods may constrain the newly predicted functions to the pharmacological functional space of the existing drugs.Clinically,many drugs have been found to bind "off-target"(i.e.to receptors other than their primary targets),which can lead to undesirable effects.In this study,which integrates known drug target information,we propose a disease-oriented strategy for evaluating the relationship between drugs and disease based on their pathway profile.The basic hypothesis of this method is that drugs exerting a therapeutic effect may not only directly target the disease-related proteins but also modulate the pathways involved in the pathological process.Upon testing eight of the global best-selling drugs in 2010(each with more than three targets),the FDA(Food and Drug Administration,USA)-approved therapeutic function of each was included in the top 10 predicted indications.On average,60% of predicted results made using our method are proved by literature.This approach could be used to complement existing methods and may provide a new perspective in drug repositioning and side effect evaluation.     

On the borderline between Science and Philosophy: A debate on determinism in France around 1880

In the second half of the nineteenth century, a new interest in explosive chemical reactions, sudden release of energy in living beings, physical instabilities, and bifurcations in the solutions of differential equations drew the attention of some scholars. New concepts like triggering actions and guiding principles also emerged. Mathematicians, physicists, physiologists, and philosophers were attracted by this kind of phenomena since they raised a question about the actual existence of a strict determinism in science. In 1878 the mathematical physicist Joseph Boussinesq pointed out a structural analogy among physical instabilities, some essential features of living beings, and singular solutions of differential equations. These developments revived long-lasting philosophical debates on the problematic link between deterministic physical laws and free will. We find in Boussinesq an original and almost isolated attempt to merge mathematical, physical, biological, and philosophical issues into a complex intellectual framework. In the last decades, some philosophers of science rediscovered the connection between physical instabilities and determinism, both in the context of chaos theory, and in the debates on the Norton dome. I put forward a consistent historical reconstruction of the main issues and characters involved.     

石蒜科植物中生物碱的药理作用研究

阐述了石蒜科(Amaryllidaceae)植物的主要药用种属和其所含生物碱的多种药理作用.石蒜科植物含有多种独特的生物活性或药理活性的生物碱类化合物,最新研究表明其具有抗肿瘤、抗白血病、抗菌抗病毒以及对心血管系统、中枢神经系统的作用等药理活性.通过对其生物碱药理作用的归纳,为石蒜科植物进一步的开发利用提供参考.     

松杉灵芝化学成分及药理活性的研究进展

松杉灵芝(Ganoderma lucidum(Curtis)P.Karst)的化学成分包括三萜、多糖、甾体、脂类、氨基酸和微量元素等。松杉灵芝具有广泛的药理学活性,主要包括抗肿瘤、抗高血脂、抗氧化、消炎等作用。本文对松杉灵芝的化学成分、药理作用进行了综述。     

持久性有机污染物研究的国际发展动态

持久性有机污染物(POPs)是指对于生物代谢、光解、化学分解等具有很强的抵抗能力的天然或人工合成的有机污染物。本文全面介绍了从有机化学品开始广泛应用到POPs成为研究热点和国际行动的焦点这一历史过程，其中详细介绍了联合国环境署18／92号决议通过后展开的国际行动。并列举了当今POPs研究的热点问题和发达国家在该领域的研究计划。     

源外斜坡区油侧向优势运移路径及控藏作用——以松辽盆地台9区块葡萄花油层为例

为了研究松辽台9区块葡萄花油层油成藏规律,在其油侧向运移条件研究的基础上,采用势能汇聚洼槽带为油气侧向运移优势路径的研究方法,对台9区块葡萄花油层油侧向运移优势路径及其控藏作用进行了研究。结果表明:台9区块通过油源断裂进入葡萄花油层中的油总体上由东向西发生侧向运移,发育5条优势运移路径,第2、4、5条优势运移路径分布距离相对较远,有利于油向西部长距离侧向运移;第1、3条优势运移路径分布距离相对较近,不利于油向西长距离侧向运移。圈闭只有位于油源断裂附近或位于优势运移路径上,才能形成油聚集,油气钻探为油区;否则远离油源断裂且又不在优势运移路径上的圈闭则不能形成油聚集,油气钻探则为水区。