Science Letters： A synthetic Toll-like receptor 2 ligand decreases allergic immune responses in a mouse rhinitis model sensitized to mite allergen

It has been proposed that activation of Toll-like receptors （TLRs） plays crucial roles in the polarization of adaptive immune responses. A synthetic Toll-like receptor 2 （TLR2） ligand, Pam3CSK4, has been reported to modulate the balance of Th1/Th2 responses. We evaluated the modulation effect of Pam3CSK4 on allergic immune response in a mouse rhinitis model sensitized to house dust mite allergen （HDM）. Mice were sensitized and challenged with Dermatophagoidesfarinae allergen （Der f）, and then the allergic mice were treated by Pam3CSK4. Nasal allergic symptoms and eosinophils were scored. Der f-specific cytokine responses were examined in the splenocytes and bronchoalveolar lavage fluid （BALF）. Serum level of total IgE was also detected. After establishing a mouse allergic rhinitis model with HDM, we have showed that Pam3CSK4 treatment not only ameliorated the nasal allergic symptoms remarkably but also decreased the eosinophils and total inflammation cells in BALF significantly. Analysis of cytokine profile found that IFN-7 released from either BALF or stimulated splenocytes increased markedly in Pam3CSK4-treated mice, while IL-13 decreased significantly. Moreover, serum level of total IgE was significantly lower in Pam3CSK4-treated mice than in the untreated. Thus, in an allergic rhinitis mouse model developed with HDM, Pam3CSK4 was shown to exhibit an antiallergic effect, indicating its potential application in allergic diseases.     

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树立地方文献品牌建设地方特色馆藏——公共图书馆地方文献的开发和利用

介绍了公共图书馆地方文献的收藏特色,论述了树立地方文献品牌的途径,提出了全面开发地方文献资源的建议。     

理想非线性单组分色谱模型理论解与实验的比较

用气相色谱的分析方法研究了理想非线性单组分不同温度下的流出曲线，用＂特征点＂法回归出了各组分的物理常数Ｇ和ｂ，代入理论模型公式，并与实验结果进行子比较。     

太阳电池I－V数据采集系统

本文利用ＩＥＥＥ－４８８接口板，Ｋｅｉｔｈｌｅｙ６１７静电计，ＩＢＭ－ＰＣ微机，编程实现了太阳电池Ｉ－Ｖ数据的自动采集、存储．以ａ－Ｓｉ：ＨＰｉｎ型太阳电池为样品，计算出相应的电池参量，验证了该系统的可行性和准确性．     

多功能剧场建筑设计与可调混响时间的应用

本文以一座大型厂矿文化宫建筑设计实例,扼要论述了多功能厅堂的设计要点,结合我国目前多功能厅堂使用状况,提出以电声为主的设计原则和实施办法,以改善多功能厅堂的音质效果。     

岩芯筒压入地层的塑性力学问题

摘要首先从库仑定律出发导出了地层介质塑性流动条件。其结果类似于一般塑性力学中的Tresca,Mises条件。其次列出了轴对称地层塑性流动的微分方程组,并推出了其简化近似方程。最后提出了简化方程的特征线解法,并举例说明。     

太白山国家森林公园游客结构及行为特征研究

基于实地问卷调查资料,通过对太白山国家森林公园的游客结构及其行为特征分析,指出其主体客源为省内大中城市居民,游客年轻化的趋势较明显且以中低收入者为主,旅游活动是以基本层次的旅游观光居优;该旅游景区的自然风光使近80%游客的美感体验得到满足、且游客感应最深的是清新空气、山地气候及森林植被等,相对较差的是宗教文化;此外,四成多的游客对旅游服务质量不满意.针对上述结果,就太白山国家森林公园开拓客流市场、促销定位、促使其可持续旅游业发展提出理性建议.     

透湿过程中织物的润湿和散湿作用

采用蒸发和吸湿法测量多种织物的透湿速率，并且仔细研究用蒸发法时，织物润湿程度在透湿过程中的变化，发现织物在透湿过程中的润湿和放湿，以及织物的表面性状是影响其放湿速率的非常重要的因素。     

一类仓库货物储存模型经典解的存在唯一性

文章用特征线法给出一类仓库货物储存模型解的递推表达式,并证明其光滑性从而得到了经典解的存在唯一性。