Enhanced urease inhibition activity of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate

Medically, bacterial ureases are important virulent factors and are used for treatment of peptic ulcers and urinary tones. Reported urease inhibitors are associated with various side effects including antibiotic resistance as a major one. Still there is an urgent need to synthesize new urease inhibitors. In this context we have synthesized new urease inhibitor i.e. AgL that is composed of Ag nanomaterials capped with N-substituted methyl 5-acetamido-β-resorcylate(L). The conjugation of L to silver was confirmed through FTIR, UV–vis and TEM analysis.Bare silver nanomaterials(Ag) were also prepared. The stability of AgL nanostructures was determined against various parameters(temperature, high salt concentration, pH) and found to be stable. The in vitro antimicrobial(antibacterial, antifungal), enzyme inhibition(xanthine oxidase, urease, carbonic anhydrase, α-chymotrypsin,cholinesterase) and antioxidant activities of AgL were investigated and compared with Ag, L and standard drugs.In comparison to other bioactivities, AgL shows statistically enhanced selective enzyme inhibition activity against urease enzyme. Urease inhibition activity of AgL was significantly greater than standard drug(thiourea),L and Ag. On a per weight basis, AgL required about 11–18 times less amount of L for inhibition of urease enzyme.     

论迪尔西形象的可靠性

迪尔西为福克纳笔下众多黑人形象之一，小说中的迪尔西既是作者的真实投射，又是基督的化身，用大爱托起了摇摇欲坠的康普生家族。她集各种美德于一身，是毅力、仁爱与忠心等美德的体现。小说的隐含作者是真实作者的反映，与真实作者是一种双向互动的关系。福克纳本人也把关爱、怜悯、同情和牺牲视作人类的普遍真理。由此可见，迪尔西与作品的隐含作者的思想规范是一致的，是故事的可靠叙述者。     

园本课程开发中家园合作的重要性

园本课程是以国家的法律法规及相关政策为指导,以幼儿园现实的环境和条件为背景,以幼儿现实的需要为出发点,以幼儿、幼儿园教师、家长和社区为主体构建的课程。园本课程在强调幼儿教师重要作用的同时,也突出了家长参与园本课程的必要性和重要作用。因此,要充分利用地域特色,调动家长参与的积极性;要打破传统的家长教育思想,提高家长的参与意识;要及时和家长沟通,获得有效反馈,等等。     

科技期刊作者自校的重要性

作者自校是指作者对其被录用的论文出版清样所做的自行校对活动，是科技期刊编辑出版疯程中的重要环节，是一种不可替代的校对形式．作者自校不但有助于编辑与作者间互助关系的形成，在一定程度上降低差错率，还能有效减少出版中的法律纠纷．     

绿色制造中的并行工程

对并行工程的内涵进行了进一步的探讨 ,指出并行工程的实质是产品生命周期的集成规划 这种产品生命周期的集成规划 ,赋予环境影响和资源因素的综合考虑 ,就构成了绿色制造的实质特征 然后 ,由此观点出发 ,探讨了绿色制造及其绿色设计中的并行工程问题 最后提出了一种绿色制造的并行工程运行模式 图 2 ,参 3     

岩石应力松弛试验及两类岩爆研究

对岩石峰值载荷后的松弛试验发现具有两类岩爆 :一类是本源型岩爆 ;另一类是激励型岩爆 两类岩爆概念的提出 ,是对现有认识的发展 应力松弛行为与岩爆的强弱程度具有内在联系 ,可以引入松弛系数R来描述岩爆冲击倾向 ,当R >1时无冲击倾向 ;当 0 .75≤R≤ 1时 ,有轻微冲击倾向 ;当R <0 .75时 ,有严重冲击倾向 图 4,表 2 ,参 4     

英语模块理论与小组合作在英语精读课中的应用

本文粗浅地阐述了在英语精读课教学中如何开展有效的小组合作学习活动,分析了英语精读课程目标与英语模块教学的本质以及小组合作学习对于落实英语模块教学的可行性;另外,从语言技能、语言知识、情感态度、学习策略和文化意识五个方面提供了英语模块教学背景下的小组合作学习教学案例,并分析了其有效性。     

基于蚁群算法的机器人足球通信机制

给出了基于蚁群算法实现机器人足球比赛中球员之间协作和通信的机制．选用两只球队分别采用了传统的通信机制和“黑板”通信机制进行实验比较，发现虽然两个球队的整体结构和高层策略相差无几，但是无论从速度、力量还是传接球成功率等方面，Novauro都比ujdb强．该通信机制具有灵活，鲁棒性强的特点，不会由于局部的失误而影响全局的性能．     

Self-cleaning property of AZ31 Mg alloy during plasma electrolytic oxidation process

The rolling of metal sheet often leads to strong contamination of the resulting surface. The present work reports the effects of the surface contamination remaining after rolling of AZ31 Mg alloy on plasma electrolytic oxidation(PEO) treatment of the resulting sheet material. Results indicate that most of the contaminants on the surface of as-rolled AZ31 Mg alloy are removed in the early stages of PEO process. The contaminations slightly influence the phase composition of PEO coating. Non-uniform distribution of contaminations results in aggregation of pores on the surface of PEO samples. On the bare substrate the contaminations are responsible for poor wear and corrosion resistance but final PEO coatings reveals similar performance on contaminated substrate compared to the abraded one. A self-cleaning property of the PEO and possibility of one step process,avoiding pre-cleaning stages, is suggested.     

Cationic polymeric nanoformulation: Recent advances in material design for CRISPR/Cas9 gene therapy

CRISPR/Cas9 (clustered regularly interspaced short palindromic repeat/clustered regularly interspaced short palindromic repeat associated proteins 9) gene editing platform is a promising therapeutic tool for genetic disorders, due to its ability to manipulate the pathogenic gene in genomic level and to easily target specific gene by manipulating single-guide RNA. However, its successful delivery remains a challenge. Up to now, great efforts have been made to explore an effective strategy for CRISPR/Cas9 delivery. But among those delivery methods, physical methods are mainly operated on cultured cells thus limited to laboratorial use; viral vectors are hindered by fetal immunogenic and carcinogenic effects thus dubious in clinical application. Therefore, cationic polymeric vectors, with the ability to interact with CRISPR/Cas9 system to form a nanoformulation as a non-viral approach, are attracting increasing attentions, due to advantages such as well protection of cargos, less limitation in payload size, low immunogenicity or carcinogenicity, potential modifications for further functions, and ease in mass production. In this review, the recent discoveries on polymeric vectors utilized in delivery of CRISPR/Cas9 system will be summarized. With emphasis on advanced features of those polymeric vectors or their nanoformulations to meet the demands of different CRISPR/Cas9 delivery forms (plasmid, mRNA or protein), the detailed illustrations on their disease treatment applications, such as cancer, diabetes or antibiotic-resistant infections, will also be reviewed.