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111.
Molecular cloning and sequence analysis of myosin genes from Arabidopsis thaliana and electron microscopic observation of a myosin from characean alga have revealed that overall structure of plant unconventional
myosins is similar to that of the class V myosins. These plant unconventional myosins have two heads, a coiled-coil tail of
varied length and a globular tail piece at the end. The tail piece is probably a site for membrane interaction. Characean
myosin is of special interest because it can translocate actin filaments at a velocity several times faster than muscle myosin,
which must have evolved to support the quick movement of animals in the struggle for their lives. 相似文献
112.
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114.
Alternative splicing of Bcl-2-related genes: functional consequences and potential therapeutic applications 总被引:6,自引:0,他引:6
Apoptosis is a morphologically distinct form of cell death. It is executed and regulated by several groups of proteins. Bcl-2 family proteins are the main regulators of the apoptotic process acting either to inhibit or promote it. More than 20 members of the family have been identified so far and most have two or more isoforms. Alternative splicing is one of the major mechanisms providing proteomic complexity and functional diversification of the Bcl-2 family proteins. Pro- and anti-apoptotic Bcl-2 family members should function in harmony for the regulation of the apoptosis machinery, and their relative levels are critical for cell fate. Any mechanism breaking down this harmony by changing the relative levels of these antagonistic proteins could contribute to many diseases, including cancer and neurodegenerative disorders. Recent studies have shown that manipulation of the alternative splicing mechanisms could provide an opportunity to restore the proper balance of these regulator proteins. This review summarises current knowledge on the alternative splicing products of Bcl-2-related genes and modulation of splicing mechanisms as a potential therapeutic approach.Received 5 January 2004; received after revision 31 March 2004; accepted 6 April 2004 相似文献
115.
卢梓 《西安联合大学学报》2002,5(1):97-99
党和国家“科教兴国”战略的提出,素质教育的实施,给学校教育提出了更高目标和要求,同时,也为美术教育提供了广阔的发展空间。美术教育应该注重非智力因素的开发,应该关注学生的兴趣,情感,想像力,自信心,个性,意志等行为的培养。通过这些非智力因素的开发,可以培养学生高尚的审美情趣,树立正确的人生观,价值观,对于加强社会主义精神文明建设具有积极意义。 相似文献
116.
陈林侠 《杭州师范学院学报(自然科学版)》2002,(2)
在《伤逝》中 ,启蒙身份的丢失是根源于面对家庭的困惑。用什么来维系家庭成员 ,这是整个五四时期启蒙者的困境。小说采用叙述与体验两种截然不同的方式建构文本 ,透露出人生的悲剧 ,更重要的是凸现出鲁迅独特的时间观。在乌托邦与反乌托邦的平衡中 ,鲁迅与现实之间难以分割的关系促使他形成了“死后之生”的人生哲学 相似文献
117.
Advances in methods of structure determination have led to the accumulation of large amounts of protein structural data. Some 500 distinct protein folds have now been characterized, representing one-third of all globular folds that exist. The range of known structural types and the relatively large fraction of the protein universe that has already been sampled have greatly facilitated the discovery of some unifying principles governing protein structure and evolutionary relationships. These include a highly skewed distribution of topological arrangements of secondary-structure elements that favors a few very common connectivities and a highly skewed distribution in the capacity of folds to accommodate unrelated sequences. These and other observations suggest that the number of folds is far fewer than the number of genes, and that the fold universe is dominated by a small number of giant attractors that accommodate large numbers of unrelated sequences. Thus all basic protein folds will likely be determined in the near future, laying the foundation for a comprehensive understanding of the biochemical and cellular functions of whole organisms. 相似文献
118.
叶虹 《浙江科技学院学报》2003,15(4):241-245
“新婚姻法现象”不仅是一个立法事件,更是当前我国婚姻家庭关系领域内伦理道德矛盾的集中反映。一部法律的修订并不能解决所有矛盾,我们迫切需要有针对性地研究新问题,加强婚姻家庭关系领域的道德建设。 相似文献
119.
家庭心理治疗理论研究综述 总被引:1,自引:0,他引:1
在系统论的观念影响下,心理治疗理论越来越倾向于以系统的观点来指导临床治疗.依据"系统学"的观念,家庭心理治疗就是将个体置于家庭这一系统之中进行分析和治疗.其方法主要包括结构性家庭治疗、系统性家庭治疗、行为家庭治疗和策略性家庭治疗等. 相似文献