奥扎格雷钠治疗急性脑梗死40例疗效观察

用奥扎格雷钠静脉滴注治疗急性脑梗死40例,并做对照研究,疗程均为半个月,结果治疗组在神经功能缺损程度评分的减少和总体有效率方面均明显优于对照组,与溶栓治疗效果相似,且无明显副作用.表明奥扎格雷钠在急性脑梗死的治疗中具有安全、方便、疗效肯定的优点,值得临床推广.     

人硫氧还蛋白对脑缺血作用的CT灌注与SOD相关性的实验研究

目的研究人硫氧还蛋白(hTRX)对局灶性兔脑缺血/再灌注损伤后脑组织的保护作用,并探讨其清除氧自由基的生物学活性.方法采用线栓法制成一侧兔脑缺血/再灌注模型(栓塞6 h,再灌注18 h),将25只雄性新西兰白兔随机分成假手术组(Sham组,5只)、缺血/再灌注组(I/R组,10只)和缺血/再灌注 hTRX治疗组(I/R hTRX组,10只),I/R hTRX组给予hTRX(0.75 mg/kg体质量),Sham组、I/R组以等容积的生理盐水取代hTRX;分别于梗死后6 h及再灌注后18 h做CT灌注图像,观察脑梗死面积,计算出其所占同侧大脑半球面积的百分比(HLA%);检测脑组织匀浆中SOD,MDA含量.结果脑缺血/再灌注后,脑梗死范围显著,脑组织匀浆中SOD明显下降,MDA明显升高(与假手术组比较,P<0.01);而应用hTRX能显著减小脑梗死面积,降低MDA及升高SOD含量(与B组比较,P<0.01).结论重组hTRX对脑缺血/再灌注损伤有显著的治疗作用.     

速碧林联合纳络酮治疗急性脑梗死疗效观察

目的观察速碧林联合纳络酮治疗急性脑梗死的临床效果。方法采用速碧林0.4ml皮下注射每天1次,纳络酮1.2m g 0.9%NS250ml静点,1次d/。结果联合用药疗效优于单一用药组(P<0.01)。结论速碧林联合纳络酮治疗急性脑梗死治愈率高,显效及肌力开始恢复的时间明显提前。     

急诊科开展神经内镜治疗高血压脑出血的临床研究

目的探讨急诊科开展神经内镜手术治疗高血压脑出血的临床价值。方法1999年7月至2003年12月我院急诊科开展神经内镜手术治疗自发性脑出血101例。对其时效性、疗效、并发症等方面进行分析。结果从入院到手术间隔时间为(68.6±38.3)min。出血部位在基底节51例,脑叶27例,丘脑9例,血肿破入脑室14例。出血量20~130ml,平均(53.3±36.8)ml。手术时机为发病7h以内36例,7~72h43例,超过72h22例。手术时机越早,其疗效越好,并发症越少(P<0.001)。同时血肿量越大,疗效越差(P<0.001)。结论急诊科应用神经内镜治疗高血压脑出血具时效性、整体性和微创性统一,扩大了手术指征,值得进一步研究和推广应用。     

Reversal of experimental hemorrhagic shock by dimethylphenylpiperazinium (DMPP)

In a rat model of hemorrhagic shock which caused the death of all control rats within 30 min, i.v. injection of the ganglion-stimulating drug dimethylphenylpiperazinium (DMPP) caused a dose-dependent reversal of the shock condition-without the need for reinfusion of the shed blood-starting from the dose of 4 ng/kg i.v. Shock reversal was associated with the mobilization of residual blood and improvement in blood flow, particularly at the carotid level. These results could influence our thinking on pathophysiology and first-aid management of shock.     

Identification of antiviral-relevant genes in the cultured fish cells induced by UV-inactivated virus

UV-inactivated grass carp hemorrhage virus (GCHV) can induce high titer of interferon in cultured CAB (Crucian carp (Carassius auratus L.) blastulae )cells,and thus defend host cells against the virus invasion ,The mechanism is proposed that an antiviral state should be established in the host cells by activating expression of a set of antiviral-relevant genes,In this study ,suppressive subtractive hybridization is applied to constructing a subtracted ,cDNA library with mRNAs isolated from UV-inactivated GCHV infected and mock-infected CAB cells,272 differential cDNA fragments are identified by both PCR and dot blot from the subtractive cDNA library .Sequencing analysis reveals 69 genes,including 46 known gene homlologues,and 23 unknown putative genes,The known genes include the gemes involved in interferon signaling pathways,such as Stat1 and Jak1,the antiviral gences,such as Mx and Vipering,and a set of interferon-stimulated genes observed in mammalian cells. Most of the unknow putative genes contain AU-rich element in their sequences,Differential expressions of these genes are further confirmed by virtual Northern blot and RT-PCR,The data imply that UV-inactivated GCHV is not only able to induce production of interferon in the infected CAB cells,but also leads to the expression of a series of antiviral-relevant genes or immune-releveant genes,and therefore reveals that the signaling pathway of interferon system and antiviral mechanism in fish are similar to those in mammals.     

产后出血96例临床分析

目的：探讨产后出血的病因及有效治疗措施。方法：回顾性分析96例产后出血患者的临床资料。结果：96例产后出血原因：宫缩乏力58例，胎盘因素27例，软产道损伤因素6例，凝血功能障碍5例。96例中61例行保守治疗，34例行宫腔填塞纱条治疗，2例行子宫次全切除术，效果满意。结论：宫缩乏力、胎盘因素是产后出血的主要原因，保守治疗无效者官腔填塞纱条是治疗产后出血、保留子宫的有效措施。必要时应及时采取子宫次全切除术。     

年轻人脑梗死临床研究

目的：研究年轻人脑梗死的病因及危险因素，方法：对31例年轻人脑梗死的病因及危险因素进行分析总结，结果：年轻人脑梗死主要病因为早发性脑动脉硬化，心源性脑栓塞是常见病因，脑动脉炎、酒精中毒等较常见，女性患者与偏头痛、吸烟、口服避孕药密切相关，结论年轻人脑梗死病因复杂，危险因素多样，加强多学科深入合作，加强对高危人群的筛查，早发现、早预防。     

Short cerebral ischemia and subsequent reperfusion and treatment with stobadine

Lipid peroxidation and activities of antioxidative enzymes were studied in the brain cortex after short (15 min) cerebral ischemia and reperfusion (10 min) in rats. Conjugated dienes (CD) and thiobarbituric acid-reactive substances (TBARS) were significantly elevated in the group of rats with ischemia followed by reperfusion in comparison to the ischemic animals. Superoxide dismutase (SOD) activity significantly increased in the group of animals with ischemia and reperfusion. No significant changes in the activities of glutathione peroxidase (GP) were observed. Stobadine administered before ischemia or before reperfusion decreased the level of TBARS. Stobadine probably prevents malondialdehyde (MDA) formation from hydroperoxide or might elevate the activity of aldehyde dehydrogenase. In contradiction to the findings after long-lasting (4 h) ischemia and subsequent reperfusion¹, no decrease in the concentration of CD or in the activity of SOD or GP was found.     

辽宁大学职工病死调查及分析

本校教职工九年共死亡１０８人，在职工人数２５１２人没有大幅度增加的情况下、死亡率逐年增加，甚至成倍增加。从年龄段分析６１￣７１岁死亡率是高，其次是５１￣６０岁，男比女高，疾病种类占首位的是恶性肿瘤，以下顺序是脑溢血，心肌梗死，肺心病。上述情况与生活环境、不良饮食习惯、烟酒嗜好、环境污染等因素危害身体健康有关。它提醒人们认清损害身体的诸因素，提高防病意识，加强自身保健能力。