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排序方式: 共有9499条查询结果,搜索用时 15 毫秒
991.
XIAN Chengyu WANG Yuanliang ZHANG Bingbing TANG Liling PAN Jun LUO Yanfeng JIANG Peng LI Dajun 《科学通报(英文版)》2006,51(22):2731-2736
Insulin-like growth factor 1 (IGF-1) promotes osteoblasts differentiation and bone formation, and its expression is induced by mechanical stretch, thus IGF-1 has been considered an effector molecule that links mechanical stimulation and local tissue responses. In this study, a mechanical stretching device was designed to apply physiological level static or cyclic stretching stimulation to osteoblasts. Different isoforms of IGF-1 mRNA were amplified by RT-PCR from the cells using respective primers and these amplified products were sequenced. An iso-form of IGF-1 splicing product was found to be selectively produced by osteoblasts under stretching stimulation. This IGF-1 isoform had identical sequence with the mechano growth factor (MGF) which was originally identified in muscle cells. Regulations of the expression of the liver-type IGF (L.IGF-1) and MGF in osteoblasts under stretch stimulation were further studied using semi-quantitative RT-PCR. Stretch stimulation was found to promot the expression of IGF-1 (L.IGF-1 and MGF), and for both isoforms expression was more effectively stimulated by cyclic stretch than static stretch. MGF was detected only in osteoblasts subjected to mechanical stretch, suggesting MGF was a stretch sensitive growth factor. Expression of MGF peaked earlier than that of L.IGF-1, which was similar to their regulation in muscle and suggested similar roles of MGF and L.IGF-1 in bone as in muscle cells. The functions of MGF and LIGF-1 in osteoblasts shall be established by further experimental studies. 相似文献
992.
陈晓生 《杭州师范学院学报(自然科学版)》2006,5(5):415-417
研究了5种1-(4-甲基-6-烃基环己-3-烯羰基)吡咯烷-2-酮衍生物的电子轰击质谱(EI-MS),从所得的质谱数据,探讨了在70 eV下该类化合物的碎片断裂机理. 相似文献
993.
Milk epithelial mucin (MUC1) of yaks was separated by SDS-polyacrylamide gel electrophoresis. A total of nine types of MUC1 were revealed in 427 yaks from five yak breeds including Maiwa yak, Jiulong yak, Tianzhu white yak, Qinghai yak and Tibetan yak. The molecular weights of MUC1 are from 163 kD to 208 kD, most of which are larger than those of bovine. Population genetic analysis shows that the gene frequency and genotype frequency of yak MUC1 differ among breeds, with relatively high gene heterozygosity. The five yak breeds studied fall into two groups according to their milk MUC1 gene frequency, suggesting that milk MUC1 exhibits specificities for local yak groups. 相似文献
994.
YAN Yin 《科技情报开发与经济》2006,(23)
50056,China)Objective To discuss the defending ability problem of raped mental retardation women. 相似文献
995.
996.
把对动态黑洞量子热效应的研究推广到用(t,r)坐标描述的时空.进一步发展了研究动态黑洞的乌龟坐标方法,给出了1+1维动态带是黑洞的视界位置和温度. 相似文献
997.
本文报道了稀土铕(Eu3+)与甲基苯甲酸(包括邻位o-MBA,间位m-MBA,对位p-MBA)及邻菲罗啉(phen)形成的二元和三元固体配合物的制备,对它们进行了元素分析,确定该配合物的组成为:二元:Eu(CH3C6H5COO)3,三元:Eu(phen)(CH3C6H5COO)3。对上述配合物的结构作了核磁共振氢谱(1HNMR)和碳谱(13CNMR)的研究,并用红外光谱(IR)作了进一步确定 相似文献
998.
999.
本文分析表明,并不存在文[1]指出的含有Grassman代数生成元的泛函导数的那种特殊性。文[1]作者的错误在于不正确地理解了源函导数的定义。详细计算证明,文[2]的结论是正确的。 相似文献
1000.