Identification of susceptibility genes loci associated with type 2 diabetes

In this study, we selected 10 susceptible SNPs loci to investigate their contribution to susceptibility to type 2 diabetes in Han Chinese among Hubei population. We genotyped SNPs rs5219, rs1801282, rs1470579, rs1111875, rs1081661, rs7754840, rs4506565, rs13266634, rs4402960, and rs5643981 by using the method of polymerase chain reaction-ligase detection reaction (PCR-LDR). In a case-control study, we have genotyped the 10 candidate susceptibility SNP loci, and here, we reported that the SNP rs5219 in KCNJ1...     

基于Pro/E的车用CNG气瓶装卸机械设计

针对车用CNG气瓶定检时人工装卸气瓶效率低、安全性差等问题,提出设计一种CNG气瓶装卸机械.该装置包括升降小车和机械抓手两部分,可实现对气瓶的抓取、旋转、升降、进退等动作.基于Pro/Engineer的三维建模功能,建立该机械装置、气瓶及车厢的3D模型,进行模拟装卸的结构干涉分析.结果表明该机械结构简单、操作方便,具有...     

微合金非调质40Mn2V钢管的变形抗力研究

采用Gleeble-1500 热模拟实验机对微合金非调质40Mn2V钢管的变形抗力进行了研究.结果表明,变形温度越高,变形速率越低,钢管变形抗力越小.变形抗力对数值lnσ随着温度升高和变形速率对数值lnε·的增大,分别呈线性减小和线性增大,且变形抗力与变形程度呈非线性关系.采用Matlab软件拟合出了微合金非调质40Mn2V钢管的变形抗力公式,其拟合度R为0.966 3.     

析当前我国大学生失业的特点

大学生失业从历史和世界的角度来考察,是一种比较普遍的社会现象。1999年高校扩招之后,我国开始出现了比较突出的大学生失业现象,并引起了人们的高度关注。当前我国大学生的失业现象具有必然性和合理性、主动性和被动性、相对性、差异性等特点,分析这些特点有助于我们全面地辩证地认识大学生失业现象。     

Medical entity and attributes extraction system based on relation annotation

The abundant entities and entity-attribute relations in medical websites are important data resources for medical research. However, the medical websites are usually characterized of storing entity and attribute values in different pages. To extract those data records efficiently, we propose an automatic extraction system which is related to entity and attribute relations (attributes and values) of separate storage. Our system includes following modules: (1) rich-information interactive annotation page rendering; (2) separate storage attribute relations annotating; (3) annotated relations for pattern generating and data records extracting. This paper presents the relations about the attributes which are stored in many pages by effective annotation, then generates rules for data records extraction. The experiments show that the system can not only complete attribute relations of separate storage extraction, but also be compatible with regular relation extraction, while maintaining high accuracy.     

重新解读网络环境下的文件生命周期理论

文件连续体理论与文件生命周期理论之争,其主因是档案学界对两种理论定位和电子文件生命周期的认识不一.本文对此从一切文件皆有生命周期、电子文件生命周期表现形式与纸质文件生命周期表现形式比较、科学认识网络环境下的文件生命周期理论三方面,运用辩证唯物史观重新解读网络环境下的文件生命周期理论.     

A bioinformatic evaluation of potential allergenicity of 85 candidate genes in transgenic organisms

The potential of genetically modified organisms(GMOs) to increase allergenicity or predispositions to allergies has attracted much attention.An approach that will properly and holistically evaluate the allergenicity of GMOs is yet to be found.Here,85 transgenes that have been reported in both international and domestic studies during recent years are summarized case by case;49 of the transformed genes were from plant sources and 36 were from animal sources.EVALLERTM,a web server for the in silico assessment of potential protein allergenicity,was used to evaluate the potential of the transgenic proteins as allergens.The biomedical journals listed in Highwire(http://highwire.stanford.edu/) were searched and reviewed to decipher whether any of the transformed genes were linked to allergenicity or human health.The EVALLER analysis identified 5 allergenic genes,whilst our literature review found 11 genes that were either related to allergic cases or to clinical adverse events;all 16 of these genes have been used in GMOs.The analysis pathway that we have developed can help guide the selection of genes to be used in genetic modification.The pathway also provides a paradigm for allergenicity analysis of transgene candidates.     

我国特色养殖业系统分析与评价

依据我国的资源、环境、技术条件及现有基础，分析了特色养殖业的风险性及适宜我国各地区养殖的品种，提出了建议性饲养管理模式。     

渣油热接触改质反应机理——Ⅱ.胶质和沥青质的转化

以添加不同数量胶质或沥青质的胜利减二线为原料油,采用2~#热载体,在固定流化床反应装置上考察了胶质、沥青质的转化。结果表明,在通常的反应条件下,胶质大部分转化为液体,沥青质大部分转化为焦炭。采用热接触改质,可脱除渣油中40～60%的S、N,90%左右重金属Ni以及85%以上的残炭,约90%的胶质和近乎100%的沥青质。     

锥篮离心机物料颗粒运动和锥篮合理曲面计算

本文研究物料颗粒沿筛篮转鼓锥形壁上升过程中的运动.通过建立颗粒的运动微分方程及其数值积分,分析了颗粒的轨迹和速度、分离因素等运动要素.以这种分析为基础,计算了在特定要求下筛篮的合理曲面形状.