全文获取类型
收费全文 | 10520篇 |
免费 | 826篇 |
国内免费 | 300篇 |
专业分类
系统科学 | 1286篇 |
丛书文集 | 140篇 |
教育与普及 | 88篇 |
理论与方法论 | 292篇 |
现状及发展 | 905篇 |
研究方法 | 24篇 |
综合类 | 8909篇 |
自然研究 | 2篇 |
出版年
2024年 | 23篇 |
2023年 | 60篇 |
2022年 | 95篇 |
2021年 | 83篇 |
2020年 | 78篇 |
2019年 | 18篇 |
2018年 | 765篇 |
2017年 | 780篇 |
2016年 | 483篇 |
2015年 | 143篇 |
2014年 | 171篇 |
2013年 | 158篇 |
2012年 | 410篇 |
2011年 | 1100篇 |
2010年 | 946篇 |
2009年 | 647篇 |
2008年 | 732篇 |
2007年 | 985篇 |
2006年 | 194篇 |
2005年 | 224篇 |
2004年 | 250篇 |
2003年 | 276篇 |
2002年 | 176篇 |
2001年 | 159篇 |
2000年 | 173篇 |
1999年 | 328篇 |
1998年 | 284篇 |
1997年 | 283篇 |
1996年 | 272篇 |
1995年 | 228篇 |
1994年 | 185篇 |
1993年 | 174篇 |
1992年 | 152篇 |
1991年 | 149篇 |
1990年 | 128篇 |
1989年 | 101篇 |
1988年 | 93篇 |
1987年 | 68篇 |
1986年 | 44篇 |
1985年 | 13篇 |
1984年 | 2篇 |
1983年 | 1篇 |
1982年 | 3篇 |
1978年 | 1篇 |
1974年 | 2篇 |
1971年 | 1篇 |
1967年 | 3篇 |
1957年 | 2篇 |
排序方式: 共有10000条查询结果,搜索用时 140 毫秒
21.
Beatriz E. Nielsen Teresa Minguez Isabel Bermudez Cecilia Bouzat 《Cellular and molecular life sciences : CMLS》2018,75(13):2457-2471
The α7 nicotinic receptor is a promising drug target for neurological and inflammatory disorders. Although it is the homomeric member of the family, a novel α7β2 heteromeric receptor has been discovered. To decipher the functional contribution of the β2 subunit, we generated heteromeric receptors with fixed stoichiometry by two different approaches comprising concatenated and unlinked subunits. Receptors containing up to three β2 subunits are functional. As the number of β2 subunits increases in the pentameric arrangement, the durations of channel openings and activation episodes increase progressively probably due to decreased desensitization. The prolonged activation episodes conform the kinetic signature of α7β2 and may have an impact on neuronal excitability. For activation of α7β2 receptors, an α7/α7 binding-site interface is required, thus indicating that the three β2 subunits are located consecutively in the pentameric arrangement. α7-positive allosteric modulators (PAMs) are emerging as novel therapeutic drugs. The presence of β2 in the pentamer affects neither type II PAM potentiation nor activation by an allosteric agonist whereas it impairs type I PAM potentiation. This first single-channel study provides fundamental basis required to decipher the role and function of the novel α7β2 receptor and opens doors to develop selective therapeutic drugs. 相似文献
22.
Laurence Canaple Aline Gréchez-Cassiau Franck Delaunay Ouria Dkhissi-Benyahya Jacques Samarut 《Cellular and molecular life sciences : CMLS》2018,75(21):3991-4005
Most living organisms show circadian rhythms in physiology and behavior. These oscillations are generated by endogenous circadian clocks, present in virtually all cells where they control key biological processes. To study peripheral clocks in vivo, we developed an original model, the Rev-Luc mouse to follow noninvasively and longitudinally Rev-Luc oscillations in peripheral clocks using in vivo bioluminescence imaging. We found in vitro and in vivo a robust diurnal rhythm of Rev-Luc, mainly in liver, intestine, kidney and adipose tissues. We further confirmed in vivo that Rev-Luc peripheral tissues are food-entrainable oscillators, not affected by age or sex. These data strongly support the relevance of the Rev-Luc model for circadian studies, especially to investigate in vivo the establishment and the entrainment of the rhythm throughout ontogenesis. We then showed that Rev-Luc expression develops dynamically and gradually, both in amplitude and in phase, during fetal and postnatal development. We also demonstrate for the first time that the immature peripheral circadian system of offspring in utero is mainly entrained by maternal cues from feeding regimen. The prenatal entrainment will also differentially determine the Rev-Luc expression in pups before weaning underlining the importance of the maternal chrononutrition on the circadian system entrainment of the offspring. 相似文献
23.
Danielle Kamato Muhamad Ashraf Rostam Rebekah Bernard Terrence J. Piva Nitin Mantri Daniel Guidone Wenhua Zheng Narin Osman Peter J. Little 《Cellular and molecular life sciences : CMLS》2015,72(4):799-808
G protein-coupled receptor (GPCR) signalling is mediated through transactivation-independent signalling pathways or the transactivation of protein tyrosine kinase receptors and the recently reported activation of the serine/threonine kinase receptors, most notably the transforming growth factor-β receptor family. Since the original observation of GPCR transactivation of protein tyrosine kinase receptors, there has been considerable work on the mechanism of transactivation and several pathways are prominent. These pathways include the “triple membrane bypass” pathway and the generation of reactive oxygen species. The recent recognition of GPCR transactivation of serine/threonine kinase receptors enormously broadens the GPCR signalling paradigm. It may be predicted that the transactivation of serine/threonine kinase receptors would have mechanistic similarities with transactivation of tyrosine kinase pathways; however, initial studies suggest that these two transactivation pathways are mechanistically distinct. Important questions are the relative importance of tyrosine and serine/threonine transactivation pathways, the contribution of transactivation to overall GPCR signalling, mechanisms of transactivation and the range of cell types in which this phenomenon occurs. The ultimate significance of transactivation-dependent signalling remains to be defined but it appears to be prominent and if so will represent a new cell signalling frontier. 相似文献
24.
LuJian-ke 《武汉大学学报:自然科学英文版》2004,9(1):1-5
The homogeneous quadratic Riemann boundary value problem (1) with Hoelder continuous coefficients for the normal case was considered by the author in 1997. But the solutions obtained there are incomplete. Here its general method of solution is obtained. 相似文献
25.
In this paper, we discuss a selection and evaluation method of customer credit for the commercial bank loans operation, and put forth a forward selection model by optimization techniques. At last, we also give an example to analyze its application. 相似文献
26.
The tracing evaluation index system was designed to be used in virtual enterprise and established neural network trace evaluation model. As a result, it was more simple and nicer than the traditional method, so it had wider application foreground. 相似文献
27.
用动电位极化和恒电位极化法研究了A3碳钢在不同浓度NaCl的0.5mol/LNaHCO3溶液中亚稳态孔蚀行为。实验发现亚稳态电流波动峰具有快速上升、缓慢下降的特点。亚稳孔出现电位Em 服从正态分布,随着Cl-浓度的提高,Em 值向负方向移动。亚稳孔的峰频变化规律与电位关系不大。恒电位极化时,当电位高于Em而大大低于孔蚀电位Eb 时,电流波动保持一定时间后会最终消失,并产生直径为微米级的小蚀孔。当电位接近孔蚀电位时,一段时间的电流波动后电流往往迅速上升,最终转变为稳定蚀孔. 相似文献
28.
Abrupt climate change:Debate or action 总被引:4,自引:1,他引:3
CHENGHai 《科学通报(英文版)》2004,49(18):1997-2002
Global abrupt climate changes have been documented by various climate records, including ice cores, ocean sediment cores, lake sediment cores, cave deposits, loess deposits and pollen records. The climate system prefers to be in one of two stable states, i.e. interstadial or stadial conditions, but not in between. The transition between two states has an abrupt character. Abrupt climate changes are, in general, synchronous in the northern hemisphere and tropical regions. The timescale for abrupt climate changes can be as short as a decade. As the impacts may be potentially serious, we need to take actions such as reducing CO2 emissions to the atmosphere. 相似文献
29.
RAOLan-lan CAIDong-han 《武汉大学学报:自然科学英文版》2004,9(4):404-406
We prove that the model with physical and human capital adjustment costs has optimal solution when the production function is increasing return and the structure of vetor fields of the model changes substantially when the prodution function from decreasing return turns to increasing return. And it is shown that the economy is improved when the coefficients of adjustment costs become small. 相似文献
30.