黄三角装备制造业区域产业专业化发展的实证分析

结合区位商分析法、数据包络分析法以及市场占有率指标法对2015年黄三角装备制造业七大行业的产业专业化程度、产业效率以及市场绩效等方面进行实证分析。结果表明:黄三角装备制造业的总体发展状况良好,七大行业的区域特征明显。针对部分城市出现的规模报酬递减以及市场占有率下滑现象,按照区域分工、优势互补、弱势协作等思路提出发展策略以实现区域经济的全面发展。     

Developing anti-neoplastic biotherapeutics against eIF4F

Biotherapeutics have revolutionized modern medicine by providing medicines that would not have been possible with small molecules. With respect to cancer therapies, this represents the current sector of the pharmaceutical industry having the largest therapeutic impact, as exemplified by the development of recombinant antibodies and cell-based therapies. In cancer, one of the most common regulatory alterations is the perturbation of translational control. Among these, changes in eukaryotic initiation factor 4F (eIF4F) are associated with tumor initiation, progression, and drug resistance in a number of settings. This, coupled with the fact that systemic suppression of eIF4F appears well tolerated, indicates that therapeutic agents targeting eIF4F hold much therapeutic potential. Here, we discuss opportunities offered by biologicals for this purpose.     

美国农业保险的实务操作规章与借鉴?

通过全面研读2012农事年美国农业保险手册,总结美国农业保险实务操作,结合我国农业保险现状,主要有以下启示:1)重视历史数据,实际产量历史数据库是农业保险的基础;2)重视可操作性,保险规章要求事无巨细,详尽规范;3)农业保险合同中的土地投保单元设置多样化.     

反思在服务学习中的作用研究

反思是服务学习的一个重要特质,也是实施过程中一个重要的阶段,是保证服务学习质量,提升服务效果的重要组成部分。本文主要从反思的理论基础,反思的特质以及反思的作用等方面阐述反思在服务学习中的地位和价值,有助于更好地开展服务学习,提升服务学习效果。     

“十三五”时期中国特色社会主义民主科学发展的现实路径

中国特色社会主义民主通过科学的规制和有序的实践,确立人民群众的历史活动主体和价值主体的地位,彰显以人为本的生态实然。"十三五"时期中国特色社会主义民主发展面临着腐败、贫富差距、制度外政治参与、借鉴西方民主等现实难题。"十三五"时期,以科学发展观为统帅,结合"四个全面"战略布局,从民主制度与民主生活的有机互动中把握中国特色社会主义民主发展的内在逻辑,构建其科学发展的现实路径。     

Disruption of calcitonin gene-related peptide signaling accelerates muscle denervation and dampens cytotoxic neuroinflammation in SOD1 mutant mice

Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Neuronal vacuolization and glial activation are pathologic hallmarks in the superoxide dismutase 1 (SOD1) mouse model of ALS. Previously, we found the neuropeptide calcitonin gene-related peptide (CGRP) associated with vacuolization and astrogliosis in the spinal cord of these mice. We now show that CGRP abundance positively correlated with the severity of astrogliosis, but not vacuolization, in several motor and non-motor areas throughout the brain. SOD1 mice harboring a genetic depletion of the βCGRP isoform showed reduced CGRP immunoreactivity associated with vacuolization, while motor functions, body weight, survival, and astrogliosis were not altered. When CGRP signaling was completely disrupted through genetic depletion of the CGRP receptor component, receptor activity-modifying protein 1 (RAMP1), hind limb muscle denervation, and loss of muscle performance were accelerated, while body weight and survival were not affected. Dampened neuroinflammation, i.e., reduced levels of astrogliosis in the brain stem already in the pre-symptomatic disease stage, and reduced microgliosis and lymphocyte infiltrations during the late disease phase were additional neuropathology features in these mice. On the molecular level, mRNA expression levels of brain-derived neurotrophic factor (BDNF) and those of the anti-inflammatory cytokine interleukin 6 (IL-6) were elevated, while those of several pro-inflammatory cytokines found reduced in the brain stem of RAMP1-deficient SOD1 mice at disease end stage. Our results thus identify an important, possibly dual role of CGRP in ALS pathogenesis.     

基于RBF网络的中国信贷规模稳健预测

将M-估计稳健损失函数与基于统计贡献度的动态确定核函数方法相结合, 提出一种有效的非参数RBF预测模型, 该方法克服了稳健性缺失问题, 在估计参数的同时动态确定最佳网络结构, 并且在学习中自动消除噪声和异常点的影响, 加快了网络的学习和收敛速度. 利用中国月度信贷数据进行实证分析表明, 本文模型与基准模型相比具有最好的预测稳健性和准确性, 对于提高货币政策有效性和前瞻性具有很好的应用价值.     

基于FDM的多进制多用户DCSK

基于传统的多用户差分混沌移位键控(differential chaos shift keying,DCSK),本文提出一种新型的多进制多用户DCSK 混沌扩频通信方案。该方案在发送端将二进制码元转换为多进制码元,极大提高了二进制码元的传输速率,并利用频分复用实现多用户传输。接收端将所有用户参考信号合并作为新的参考信号,分别与各个用户进行相关解调。仿真结果表明,增加用户数可以有效改善多进制多用户DCSK系统的误码性能,该方案具有一定的实际应用价值。     

Liquidity dynamics around intraday price jumps in Chinese stock market

Using 4128 single jumps detected from high frequency data of 220 individual stocks in SZ300P index, this paper investigates the liquidity dynamics around price jumps in Chinese market. Some interesting empirical results are obtained and the corresponding explanations are given. The frequency of positive jumps is quite higher than that of negative jumps. The trading volumes and average trade sizes are all in a high level around positive jumps. The relatively low liquidities around negative jumps show that negative jumps may be generated and enlarged by poor liquidity provision. The price reversal after price jumps is significant, and price reversal lasts longer after positive jumps. Moreover, the size and direction of jumps are significantly correlated with the returns and trades in the post-jump trading time. These findings are believed to be associated with the high proportion of retail investors and their herding behavior for price trend chasing.     

ATP-induced Ca<Superscript>2+</Superscript>-signalling mechanisms in the regulation of mesenchymal stem cell migration

The ability of cells to migrate to the destined tissues or lesions is crucial for physiological processes from tissue morphogenesis, homeostasis and immune responses, and also for stem cell-based regenerative medicines. Cytosolic Ca²⁺ is a primary second messenger in the control and regulation of a wide range of cell functions including cell migration. Extracellular ATP, together with the cognate receptors on the cell surface, ligand-gated ion channel P2X receptors and a subset of G-protein-coupled P2Y receptors, represents common autocrine and/or paracrine Ca²⁺ signalling mechanisms. The P2X receptor ion channels mediate extracellular Ca²⁺ influx, whereas stimulation of the P2Y receptors triggers intracellular Ca²⁺ release from the endoplasmic reticulum (ER), and activation of both type of receptors thus can elevate the cytosolic Ca²⁺ concentration ([Ca²⁺]_c), albeit with different kinetics and capacity. Reduction in the ER Ca²⁺ level following the P2Y receptor activation can further induce store-operated Ca²⁺ entry as a distinct Ca²⁺ influx pathway that contributes in ATP-induced increase in the [Ca²⁺]_c. Mesenchymal stem cells (MSC) are a group of multipotent stem cells that grow from adult tissues and hold promising applications in tissue engineering and cell-based therapies treating a great and diverse number of diseases. There is increasing evidence to show constitutive or evoked ATP release from stem cells themselves or mature cells in the close vicinity. In this review, we discuss the mechanisms for ATP release and clearance, the receptors and ion channels participating in ATP-induced Ca²⁺ signalling and the roles of such signalling mechanisms in mediating ATP-induced regulation of MSC migration.