经砷诱导人肝细胞L02获得砷耐受性的研究

砷是自然界普遍存在的毒性较强的类金属元素。几乎所有生物在进化中都产生了对砷毒性的耐受性。生物体对砷的耐受机制受到广泛关注。本实验采用低剂量(4μmol／L)NaAsO2诱导人体正常肝细胞株LO2,利用噻唑兰检测法(MTT)计算细胞生存率及半数致死量反映细胞对砷耐受性的改变，结果发现低剂量砷诱导6周后，在48h急性砷中毒试验中，实验组LC50为23．0μmol／L，对照组为11．9μmo1／L，实验组明显高于对照组，说明细胞对急性砷中毒耐受性明显提高。     

高速柔性转子动平衡中VC++与MATLAB混合编程的应用

文章介绍了利用 VC+ + 与 MATALB对高速柔性转子动平衡进行混合编程计算的方法 ,与以往应用的老程序相比较 ,该程序在数据结构、数据处理和面向对象的应用上存在较大的优越性 .应用结果表明 :用 VC+ + 与 MATLAB的混合编程能够满足高速柔性转子动平衡计算的各种要求     

BPANN在仪表线性化中的应用

讨论了传感器、仪表利用软件实现线性化的优点及反向逆传播人工神经网络(BPANN)的构成，研究了半导体热敏电阻(SCTR)线性化的BPANN方法，并用MATLAB具体实现，得到了SC—TR的线性特性．用插值法检验了该方法的有效性。     

气体输运过程的讨论

采用简化假设的理论和考虑到气体分子自由程的分布及麦克斯韦速度分布律的初级理论这两种方法近似计算输运系数，并指出简化假设理论与实际情形的差异，同时就简化假设理论能得到与精确程度较高的初级理论相同结果的原因进行讨论。     

NPP distribution related to the terrains along the North-South Transect of Eastern China

Vegetation net primary productivity (NPP) is defined as the accumulative amount of organic matters per unit area and time, which is calculated from the difference between accumulative photosynthesis and accumulative autotrophic respiration by green plants. Since the NPP reflects the physiological and ecological characteristics of the plants and the interactive results of the environmental factors, it is an important index to evaluate a structure of ecological system, functional features and …     

RNA interference-mediated inhibition of Hepatitis B Virus replication

Persistent and recurrent infection of hepatitis B virus (HBV) represents one of the most common and severe viral infections of humans, and has caused a formidable health problem in the affected countries. Currently used antiviral drugs have a very limited success on controlling HBV replication and infection. RNA interference (RNAi), a process by which double-stranded RNA (dsRNA) directs sequence-specific degradation of target mRNA in mammalian and plant cells, has recently been used to knockdown gene expression in various species. In this study, we sought to determine whether RNAi-mediated silencing of HBV viral gene expression could lead to the effective inhibition of HBV replication. We first developed RNAi vectors that expressed small interfering RNA (siRNA) and targeted the HBV core or surface gene sequence. Our results demonstrated that these specific siRNAs efficiently reduced the levels of corresponding viral RNAs and proteins, and thus suppressed viral replication. Treatment with siRNA gave the greatest reduction in the levels of HBsAg (92%) and in HBeAg (85%) respectively in the cultured cell medium. Our findings further demonstrated that the RNAi-mediated antiviral effect was sequence-specific and dose-dependent. Therefore, our findings strongly suggest that RNAi-mediated silencing of HBV viral genes could effectively inhibit the replication of HBV, hence RNAi-based strategy should be further explored as a more efficacious antiviral therapy of HBV infection.     

MRTD和高阶FDTD算法的数值色散特性的分析

时域多分辨分析（MRTD）算法和高阶时域有限差分法（HO-FDTD）是目前解决电大尺寸电磁结构仿真的有效手段。导出了基于Daubechies小波尺度函数的MRTD算法和HO-FDTD算法的通用差分公式和数值色散方程，并详细讨论了空间步长、时间步长以及电磁波传播方向对二者数值色散误差的影响。结果证明，MRTD算法与HO-FDTD算法非常相似，但HO-FDTD算法的数值色散特性优干具有相同展开项个数的MRTD算法。     

A HEURISTIC PATH-PLANNING METHOD FOR ENHANCING MACHINE-TOOL CONTOUR-FOLLOWING

Nomenclature ki integral action coefficient[s-1]kp speed proportional gain[s-1]kv position proportional gain[s-1]kf feed forward factor of the speed loop[%]M axis mass[kg]V speed[m/s]F driving effort[N]Rc radius of curvature[m]d distance to the apex[m]o lateral offset[m]εcontouring error[m]ωm lowest mechanical resonant frequency[s-1]ζdamping coefficient[-]r inertia ratio[-]μmembership function[-]αcorner angle[rad]x,y horizontal and vertical coordinates[m]?angle to the normal line[rad]1.I…     

MERGING OPTIMALITY CONDITIONS WITH GENETIC ALGORITHM OPERATORS TO SOLVE SINGLE MACHINE TOTAL WEIGHTED TARDINESS PROBLEM

1.Introduction Production sequencing and scheduling is one of the most important activities in production planning and control.Sequencing is defined as the order in which the jobs are processed through the machines.The allocation of machines over time to process a collection of jobs is defined as Scheduling.Several methods have been developed to solve the scheduling problem which can be classified as follows:1)efficient optimal methods,2)implicit and explicit,or complete enumerative methods,a…     

"太白则《史记》"解绎

明人杨慎所谓"太白则<史记>"之说,行文过简.如果从司迁与李白经历和创作的相似之处,司迁与李白思想的相通之处,司迁与李白世界观和美学观的相同之处等三方面入手加以解绎,对于他们的比较研究是很有意义的.本文略异详同,旨在寻绎汉唐两代文学巨匠的同步轨迹.