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排序方式: 共有96条查询结果,搜索用时 9 毫秒
71.
Expression of human immune interferon cDNA in E. coli and monkey cells 总被引:118,自引:0,他引:118
P W Gray D W Leung D Pennica E Yelverton R Najarian C C Simonsen R Derynck P J Sherwood D M Wallace S L Berger A D Levinson D V Goeddel 《Nature》1982,295(5849):503-508
72.
David Wallace 《Studies in History and Philosophy of Science Part B: Studies in History and Philosophy of Modern Physics》2009,40(3):209-222
A systematic analysis is made of the relations between the symmetries of a classical field and the symmetries of the one-particle quantum system that results from quantizing that field in regimes where interactions are weak. The results are applied to gain a greater insight into the phenomenon of antimatter. 相似文献
73.
A de novo Alu insertion results in neurofibromatosis type 1. 总被引:43,自引:0,他引:43
M R Wallace L B Andersen A M Saulino P E Gregory T W Glover F S Collins 《Nature》1991,353(6347):864-866
74.
连法增 《东北大学学报(自然科学版)》1995,(3)
研究了干磨和湿磨,烧结和后烧工艺对磁体性能及氧含量的影响.磁体的氧含量主要来源于制粉阶段.干磨工艺磁体氧含量比湿磨磁体氧含量少一半多.合理的烧结与后烧工艺对磁体氧含量影响不大.合金锭中α-Fe的减少可改善磁体性能.Nd14.5Fe79B6.5磁体性能为iHc=696kA/m,Br=1.39T,(BH)max=368kJ/m3. 相似文献
75.
Histidinaemic mutant in the mouse 总被引:3,自引:0,他引:3
76.
Jin Y Birlea SA Fain PR Ferrara TM Ben S Riccardi SL Cole JB Gowan K Holland PJ Bennett DC Luiten RM Wolkerstorfer A van der Veen JP Hartmann A Eichner S Schuler G van Geel N Lambert J Kemp EH Gawkrodger DJ Weetman AP Taïeb A Jouary T Ezzedine K Wallace MR McCormack WT Picardo M Leone G Overbeck A Silverberg NB Spritz RA 《Nature genetics》2012,44(6):676-680
We previously reported a genome-wide association study (GWAS) identifying 14 susceptibility loci for generalized vitiligo. We report here a second GWAS (450 individuals with vitiligo (cases) and 3,182 controls), an independent replication study (1,440 cases and 1,316 controls) and a meta-analysis (3,187 cases and 6,723 controls) identifying 13 additional vitiligo-associated loci. These include OCA2-HERC2 (combined P = 3.80 × 10(-8)), MC1R (P = 1.82 × 10(-13)), a region near TYR (P = 1.57 × 10(-13)), IFIH1 (P = 4.91 × 10(-15)), CD80 (P = 3.78 × 10(-10)), CLNK (P = 1.56 × 10(-8)), BACH2 (P = 2.53 × 10(-8)), SLA (P = 1.58 × 10(-8)), CASP7 (P = 3.56 × 10(-8)), CD44 (P = 1.78 × 10(-9)), IKZF4 (P = 2.75 × 10(-14)), SH2B3 (P = 3.54 × 10(-18)) and TOB2 (P = 6.81 × 10(-10)). Most vitiligo susceptibility loci encode immunoregulatory proteins or melanocyte components that likely mediate immune targeting and the relationships among vitiligo, melanoma, and eye, skin and hair coloration. 相似文献
77.
Painter JN Anderson CA Nyholt DR Macgregor S Lin J Lee SH Lambert A Zhao ZZ Roseman F Guo Q Gordon SD Wallace L Henders AK Visscher PM Kraft P Martin NG Morris AP Treloar SA Kennedy SH Missmer SA Montgomery GW Zondervan KT 《Nature genetics》2011,43(1):51-54
Endometriosis is a common gynecological disease associated with pelvic pain and subfertility. We conducted a genome-wide association study (GWAS) in 3,194 individuals with surgically confirmed endometriosis (cases) and 7,060 controls from Australia and the UK. Polygenic predictive modeling showed significantly increased genetic loading among 1,364 cases with moderate to severe endometriosis. The strongest association signal was on 7p15.2 (rs12700667) for 'all' endometriosis (P = 2.6 × 10??, odds ratio (OR) = 1.22, 95% CI 1.13-1.32) and for moderate to severe disease (P = 1.5 × 10??, OR = 1.38, 95% CI 1.24-1.53). We replicated rs12700667 in an independent cohort from the United States of 2,392 self-reported, surgically confirmed endometriosis cases and 2,271 controls (P = 1.2 × 10?3, OR = 1.17, 95% CI 1.06-1.28), resulting in a genome-wide significant P value of 1.4 × 10?? (OR = 1.20, 95% CI 1.13-1.27) for 'all' endometriosis in our combined datasets of 5,586 cases and 9,331 controls. rs12700667 is located in an intergenic region upstream of the plausible candidate genes NFE2L3 and HOXA10. 相似文献
78.
79.
Potent ulcerogenic actions of platelet-activating factor on the stomach 总被引:27,自引:0,他引:27
Platelet-activating factor (PAF) is an endogenous phospholipid which has been implicated as a mediator of allergic and inflammatory processes. It is synthesized and released by neutrophils, platelets, macrophages, monocytes, basophils and endothelial cells, and is a potent platelet-aggregating agent, a vasodilator, increases vascular permeability, stimulates neutrophil aggregation and degranulation and induces release of lysosomal enzymes. A role for PAF in the hypotension associated with endotoxin shock and in necrotizing enterocolitis has recently been suggested. As there is an association between septic shock and acute gastric damage, we propose that PAF is an endogenous mediator of ulceration in the stomach. Indeed, as reported here, intravenous (i.v.) infusion of PAF to rats, at doses of 20-200 pmol per kg per min, resulted in the formation of extensive haemorrhagic erosions in the gastric mucosa. The ulcerogenic actions of PAF are not attributable solely to its hypotensive actions and were not mediated via effects on platelets or cyclooxygenase products, nor via histamine H1, H2 or alpha-adrenergic receptors. PAF is the most potent gastric ulcerogen yet described and its endogenous release may underlie or contribute to certain forms of gastric ulceration. 相似文献
80.
Acetylcholine receptor-aggregating factor is similar to molecules concentrated at neuromuscular junctions 总被引:3,自引:0,他引:3
The basal lamina in the synaptic cleft of the vertebrate skeletal neuromuscular junction contains molecules that direct the formation of synaptic specializations in regenerating axons and muscle fibres. We have undertaken a series of experiments aimed at identifying and characterizing the molecules responsible for the formation of one of these specializations, the aggregates of acetylcholine receptors (AChRs) in the muscle fibre plasma membrane. We began by preparing an insoluble, basal lamina-containing fraction from Torpedo californica electric organ, a tissue which has a far higher concentration of cholinergic synapses than muscle, and showing that this fraction caused AChRs on cultured chick myotubes to aggregate. A critical step is learning whether or not the electric organ factor is similar to the receptor-aggregating molecule in the basal lamina at the neuromuscular junction. The importance of this problem is emphasized by reports that clearly non-physiological agents, such as positively charged latex beads, can cause AChR aggregation on cultured muscle cells. We have already shown that Torpedo muscle contains an AChR-aggregating factor similar to that of electric organ, although in much lower amounts. Here we demonstrate, using monoclonal antibodies, that the AChR-aggregating factor in our extracts of electric organ is, in fact, antigenically related to molecules concentrated in the synaptic cleft at the neuromuscular junction. 相似文献